Ludwig-Maximilians-Universitat München

Sebastian Karpf

Robert Alexander Huber

Matthias Eibl

Wolfgang Wieser

Thomas Klein

Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.

System and method for inducing and detecting multi-photon processes in a sample

Disclosed herein is a system () for measuring light induced transmission or reflection changes, in particular due to stimulated Raman emission. The system comprises a first light source () for generating a first light signal having a first wavelength, a second light source () for generating a second light signal having a second wavelength, an optical assembly () for superposing said first and second light signals at a sample location (), and a detection means () for detecting a transmitted or reflected light signal, in particular a stimulated Raman signal caused by a Raman-active medium when located at said sample location. Here in at least one of the first and second light sources () is one or both of actively controllable to emit a time controlled light pattern or operated substantially in CW mode and provided with an extra cavity modulation means () for generating a time controlled light pattern. The detection means () is capable of recording said transmitted or reflected light signal, in particular stimulated Raman signal, as a function of time.

System and method for stimulated raman spectroscopy

Disclosed herein is a coherent dynamically controllable narrow band light source (), comprising a first sub-light source (), said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, a Raman active medium () suitable to cause Raman scattering of light having said first wavelength, a second sub-light source () capable of emitting light with a second wavelength, said second wavelength being longer than said first wavelength, and an optical fiber or wave guide, wherein said light emitted by said first and second sub-light sources traverses a length of said optical fiber () or wave guide in a feed-forward configuration to facilitate a non-linear wavelength conversion step involving said Raman-active medium. At least one of said first and second sub-light sources () has a coherence length longer than 0.05 mm, preferably longer than 0.5 mm and most preferably longer than 2 mm.

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Munich, Germany

Sebastian Karpf