Roche Diagnostics Operations, Inc.

Hoffmann-la Roche Inc.

Roche Molecular Systems, Inc.

Ventana Medical Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Sebastian Dziadek

Hans-Peter Josel

Frank Bergmann

Christoph Seidel

Luisa De Cola

Robert Cysewski

Jesus Miguel Fernandez Hernandez

Guy Georges

Ulrich Brinkmann

Stefan Dengl

Joerg Benz

Eike Hoffmann

Alexander Haas

Michael Grote

Michael Schraeml

Birgit Bossenmaier

Michael Gerg

Valeria Lifke

Patrick C Roche

Monika Soukupova

Alexander Lifke

Thomas Schindler

Elena Longhi

Lars Hillringhaus

Bernhard Reis

Michel Achille Edouard Theron

Moritz Marcinowski

Everson Nogoceke

Barbara Ecabert

Ana Patricia Bento Pereira Da Silva

Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.

Covalently linked antigen-antibody conjugates

The present invention relates to isolated antibodies, or an antigen portions thereof, which bind to human HER3. The novel antibodies are of great utility since they allow for the sensitive and specific detection of human HER3. Detection of human HER3 is, e.g., possible in a tissue sample, even when such tissue sample is a formalin-fixed paraffin embedded tissue (FFPET) sample.

Antibodies specifically binding to HER3

The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

Iridium-based complexes for ECL

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Benediktbeuern, Germany

Sebastian Dziadek