Boehringer Ingelheim International Gmbh

Sebastian Carotta

Thorsten K Oost

Martin Thomas Fleck

Harald Engelhardt

Dirk Scharn

Marco Hans Hofmann

Marc Kerenyi

Heribert Arnhof

Georg Dahmann

Herbert Nar

Sandra Handschuh

Cédrickx Godbout

Ulrich Reiser

Matthias Treu

Christian Andreas Kuttruff

The present invention relates to heterocyclic compounds of formula (I) capable of activating STING (Stimulator of Interferon Genes).

Heterocyclic compounds capable of activating STING

The present invention encompasses compounds of formula (I) wherein the groups Rto R, A and q have the meanings given in the claims and specification, their use as inhibitors of CDK8/19, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases. 

[1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors

The present invention encompasses compounds of formula (I) wherein the groups Rto R, A, X and q have the meanings given in the claims and specification, their use as inhibitors of CDK8/19, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases. 

Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors

The present invention relates to compounds of general formula I, wherein the groups R, Rand Rare defined as in claim, which have valuable pharmacological properties, particularly are modulators of STING.

Cyclic dinucleotide compounds

Compounds of formula (I) wherein Baseand Baseare defined as in claimare modulators of STING.

Modified cyclic dinucleotide compounds

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Vienna, Austria

Sebastian Carotta