Dexcom, Inc.

Alcon Research, Ltd.

Sebastian Böhm

Peter C Simpson

Daiting Rong

Apurv Ullas Kamath

Thomas Arnold Peyser

Arturo Garcia

Stephen J Vanslyke

Michael J Estes

Disha B Sheth

Leif N Bowman

Naresh Chandra Bhavaraju

Andrew Attila Pal

Dmytro Sokolovsky

Paul V Neale

Anna Leigh Davis

Anna Leigh Rack-Gomer

Robert James Boock

Aarthi Mahalingam

Matthew D Wightlin

Anna Claire Harley-Trochimczyk

Minglian Shi

Kamuran Turksoy

Lucas Bohnett

James H Brauker

Jack Pryor

Daniel Steven Kline

Jacob S Leach

Leslie Ann Field

Jason M Halac

Shawn Larvenz

Mark Dervaes

Rui Ma

Jennifer Blackwell

Antonio C Llevares

Steve Masterson

Kaushik Aroonkumar Patel

Ted Tang Lee

Jeff Jackson

Phong Lieu

Jonathan Hughes

Jason Mitchell

David DeRenzy

Antonio Ubach

Shanger Wang

Matthew J A Rickard

Thomas Miller

Jiong Zou

Adam J Livingston

Pradnya Prakash Samant

Devon M Headen

Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition.

Implantable sensor devices, systems, and methods

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Advanced analyte sensor calibration and error detection

Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously.

Systems and methods for processing analyte sensor data

Systems and methods disclosed here provide ways to discriminate fault types encountered in analyte sensors and systems and further provide ways to process such discriminated faults responsively based on sensor data, clinical context information, and other data about the patient or patient's environment. The systems and methods thus employ clinical context in detecting and/or responding to errors or faults associated with an analyte sensor system, and discriminating the type of fault, and its root cause, particularly as fault dynamics can appear similar to the dynamics of physiological systems, emphasizing the importance of discriminating the fault and providing appropriate responsive processing. Thus, the disclosed systems and methods consider the context of the patient's health condition or state in determining how to respond to the fault.

Fault discrimination and responsive processing based on data and context

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Method of making a sensor device

This document discusses, among other things, systems and methods to compensate for the effects of temperature on sensors, such as analyte sensor. An example method may include determining a temperature-compensated glucose concentration level by receiving a temperature signal indicative of a temperature parameter of an external component, receiving a glucose signal indicative of an in vivo glucose concentration level, and determining a compensated glucose concentration level based on the glucose signal, the temperature signal, and a delay parameter.

Systems, devices, and methods to compensate for temperature effects on sensors

The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator.

Transcutaneous analyte sensors, applicators therefor, and associated methods

A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor devicecomprises an in vivo portionconfigured for insertion under the skinof the host and an ex vivo portionconfigured to remain above the surface of the skinof the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing elementconfigured for piercing the skinof the host and a sensor bodycomprising a material or support memberthat provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portionmay be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.

Transcutaneous analyte sensor

Growing community of inventors

San Diego, CA, United States of America

Sebastian Böhm