Sunesis Pharmaceuticals, Inc.

Novartis Ag

Sean Ritchie

Ahmad Hashash

Anantha R Sudhakar

Hengqin Cheng

Jeff Jacobs

Augustus O Okhamafe

Rampurna Gullapalli

Kangwen L Lin

Peng Shen

Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially pure and essentially free of visible particles.

Stable SNS-595 compositions and methods of preparation

Formulations are provided, comprising: a compound of Formula I, a pharmaceutically acceptable salt thereof, or a mixture of any two or more thereof; and an ingredient selected from a hydrophilic solvent, a lipophilic solvent, an emulsifier, or a mixture of any two or more thereof; wherein the compound of Formula I is: In some embodiments, the formulations are liquids. In other embodiments, the formulations are solids. Also provided are methods of preparing such formulations.

Formulations for benzimidazolyl pyridyl ethers

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Fremont, CA, United States of America

Sean Ritchie