Foundation Medicine, Inc.

Sean R Downing

Doron Lipson

Philip James Stephens

Alexander Nevin Parker

Roman Yelensky

Geoffrey Alan Otto

Mikhail G Shapiro

Matthew J Hawryluk

Mima Jarosz

Mirna Jarosz

Alexander N Parker

Novel RET fusion molecules and uses are disclosed.

KIF5B-RET fusion molecules and uses thereof

A method of analyzing a tumor sample comprising:

Optimization of multigene analysis of tumor samples

A method is provided for identifying a patient having a respiratory illness and administering to the patient a combination of an anti-inflammatory agent and a leukotriene inhibitor. The method may include treating respiratory illness associated with a coronavirus, and may it may further include reducing or preventing an inflammatory response or cytokine storm for those patients without impairing their immune response against the underlying pathogen.

Treatment for severe acute respiratory illness associated with coronavirus

Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one or more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least exon 12 of RET or a fragment thereof (e.g., exons 12-20 of RET or a fragment thereof).

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Methuen, MA, United States of America

Sean R Downing