Vanderbilt University

Sean R Bollinger

Craig William Lindsley

P Jeffrey Conn

Paul K Spearing

Darren W Engers

Colleen M Niswender

Rory A Capstick

Andrew S Felts

Julie L Engers

Corey R Hopkins

James C Tarr

Madeline Long

Thomas M Bridges

Katrina A Bollinger

Joe Panarese

PJeffrey Conn

Indazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction.

Indazole compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Indazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Pyridine quinoline compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease states associated with glutamate dysfunction. 

Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Disclosed herein are tricyclic compounds, including pyrimido[4',5&#x2032;:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3&#x2032;,2&#x2032;:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2&#x2032;,3&#x2032;:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3&#x2032;,2&#x2032;:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4&#x2032;,5&#x2032;:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M(mAChR M). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Positive allosteric modulators of the muscarinic acetylcholine receptor M4

Disclosed herein are pyrido[3',2&#x2032;:4,5]thieno[2,3-d]pyridazin-8-amine and thieno[2,3-c:4,5-d&#x2032;]dipyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M(mAChR M). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Disclosed herein are pyrido[3',2&#x2032;:4,5]thieno[3,2-d]pyrimidine and pyrimido[4&#x2032;,5&#x2032;:4,5]thieno[2,3-c]pyridazine compounds, which may be useful as positive allostenc modulators of the muscarinic acetylcholine receptor M(mAChR M). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Growing community of inventors

Murfreesboro, TN, United States of America

Sean R Bollinger