University of Colorado

Spyglass Pharma, Inc.

Sean Maass

Malik Y Kahook

Craig Alan Cable, Ii

Glenn R Sussman

Rudolph F Zacher

Embodiments disclosed herein generally relate to an intraocular drug delivery system configured for implantation into an eye of a subject. The intraocular drug delivery system can include an intraocular lens (IOL) and a drug delivery component. The IOL includes an anterior side, a posterior side opposite the anterior side, a lens bordered by an edge and a haptic extending outwardly from the edge of the lens at a lens-haptic junction. The haptic includes, at the lens-haptic junction, a relief cut on the posterior side of the IOL. The drug delivery component includes a therapeutic agent and a fixation portion having an opening configured to receive the haptic therethrough. The fixation portion is configured to be secured to the relief cut of the haptic such that outward movement of the drug delivery component relative to the lens is inhibited.

Stabilized intraocular drug delivery systems and methods of use

Embodiments disclosed herein relate to systems and methods for securing a drug delivery component to an intraocular lens (IOL) assembly. The systems generally include a support base and a plunger. The support base includes a first portion configured to accommodate a drug delivery component; and a second portion configured to act as a plunger guide. The plunger can be inserted into the plunger guide such that the plunger is positioned to interface with a drug delivery component and an IOL assembly during use. The plunger includes an elongated body and a tip, wherein the tip can include a ramp configured to interface with a fixation loop of a drug delivery component during use and a compartment configured to interface with a haptic of an IOL assembly during use.

Systems to affix devices to intraocular lens assemblies and related methods

Embodiments disclosed herein generally relate to a stabilized intraocular drug delivery system for implantation into an eye of a subject. The system can include an intraocular lens (IOL) assembly and a drug delivery component. The IOL assembly can include a lens and a haptic. The haptic can include an outer end, an inner end opposite the outer end, a retention tab at the inner end, and a connection tab positioned between the outer end and the inner end and adjoining the lens. The drug delivery component can include at least one therapeutic agent and a fixation portion having an opening to receive the haptic and secure the drug delivery component to the IOL assembly. The fixation portion of the drug delivery component can be secured to the connection tab of the haptic such that the retention tab inhibits movement of the drug delivery component relative to the IOL assembly.

Growing community of inventors

Aliso Viejo, CA, United States of America

Sean Maass