Bristol-myers Squibb Compnay

Sean M Tonzi

Michael Politino

William V Burnett

John J Usher

Thomas J Franceschini

Guna Romancik

Suo Win Liu

Ross Binder

Joanne L Brown

Shu-Jen Chiang

David A Lowe

The invention provides a glutaryl 7-ACA amidase fromstrain BS-203, which catalyzes the hydrolysis of 7-&#x3b2;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.

Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203

The present invention relates to a novel D-hydantoinase from that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression vectors including the nucleic acids; and host cells capable of expressing the enzyme.

D-hydantoinase from Ochrobactrum anthropi

The invention provides a glutaryl 7-ACA amidase from strain BS-203, which catalyzes the hydrolysis of 7-&bgr;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.

The instant invention provides nucleic acid molecules encoding cephalosporin esterase from Rhodosporidium toruloides. In addition, the invention provides isolated cephalosporin esterase, expression vectors, host cells, and methods of producing cephalosporin esterase.

Cephalosporin esterase gene from Rhodosporidium toruloides

Nucleic acids coding for penicillin V amidohydrolase (PVA) from Fusarium oxysporum. Also, expression vectors, host cells and a method for production of PVA.

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Skaneateles, NY, United States of America

Sean M Tonzi