Ribozyme Pharmaceuticals, Incorporated

Dashamerica, Inc.

Sean M Sullivan

Kenneth G Draper

James A McSwiggen

Dan T Stinchcomb

Susan Grimm

Mark Kerns

Christopher J King

Jonathan Robert Knoll

Kevin Kisich

Tracy Byrnes

The present invention relates to a reduced abrasion shoe. The reduced abrasion shoe comprises strategically removing seams from the interior cavity of the shoe. In particular, the tongue traversing the throat is attached to the exterior surface of the upper about the toe box. A full liner between the upper and the interior cavity is coupled to the upper about the shoe mid-point. Finally, exterior surface patches are coupled to the exterior surface using a fusion bond instead of a stitch to remove the corresponding interior seam.

Reduced skin abrasion shoe

The present invention relates to a shoe having a canopy and laterally mounted tightening apparatus. The canopy has a fixed end attached to the shoe and a free end not attached to the shoe. The free end of the canopy has lobes (or the canopy is a plurality of straps) that are moveable relatively independently of each other such that a lace attached to a tightening apparatus and the free end of the canopy tightens the shoe allowing the free ends of the canopy to facilitate the canopy molding the foot of the user.

Shoe tightening system

Athletic gloves used by a person when operating a bicycle include a plurality of three-layer palm pads that are glued to a plurality of spaced positions on the palm of each glove without the use of stitching and the like. Each of the palm pads is formed of a three-layer assembly, i.e. a relatively thin heat-activated adhesive layer, a relatively thick and intermediate synthetic foam layer, and a relatively thin synthetic leather layer. Prior to assembly of a three-layer palm pad onto the palm of a glove, each of the three layers of the palm pad assembly is of a uniform thickness. A heat press having a pattern of downward-extending metal line areas, including one metal line area that matches and completely encircles the circumferential edge of each palm pad, operates to press each palm pad down onto the palm of the glove. This heat and line pressure operates to activate the palm pad adhesive layer, to thereby provide a thin line seal at the edge of each palm pad, and to also provide a pattern of thin depressed lines within each palm pad. This pattern of thin depressed lines operate to form a plurality of raised or embossed pad areas within each palm pad. The palm pads and their pad areas are strategically located on the palm of a user's hand to facilitate the bending of the glove, as the user's hand grasps an object such as the handlebar of a bicycle.

Athletic gloves for use when cycling and method of making

The present invention relates to enzymatic RNA molecules which cleave ICAM-1 mRNA.

Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (CAM-1)

Enzymatic RNA molecules which cleave ICAM-1 mRNA.

Ribozyme treatment of diseases or conditions related to levels of

Intercellular adhesion molecule-1 (ICAM-1) ribozymes

Enzymatic RNA molecules which cleave TNF-.alpha. mRNA.

TNF-.alpha. ribozymes

Enzymatic RNA molecules which cleave IL-5 mRNA.

IL-5 targeted ribozymes

An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an inflammatory disease.

Ribozymes targeted to TNF-.alpha. RNA

This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.

Growing community of inventors

Boulder, CO, United States of America

Sean M Sullivan