Theravance, Inc.

Theravance Biopharma R&d Ip, LLC

Advanced Medicine, Inc.

Axys Pharmaceuticals, Inc.

Sean Gary Trapp

Michael Robert Leadbetter

Daniel D Long

Paul Ross Fatheree

Martin Sheringham Linsell

John R Jacobsen

YongQi Mu

Guang Yu Yang

Daniel Marquess

J Kevin Judice

Yan Zhu

Sabine Axt

Bernice M T Lam

James Bradley Aggen

Edmund J Moran

S Derek Turner

Priscilla M Van Dyke

Robert Murray McKinnell

Lan Jiang

Miroslav Rapta

Daisuke Roland Saito

Timothy J Church

Pierre-Jean Colson

Matthew B Nodwell

Ying Yu

Thomas E Jenkins

Wendy B Young

Erik Joel Verner

Robert Murray Mckinnell

Derek S Turner

The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R, R, R, R, R, and Rare defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists

The invention provides amino- and amido-aminotetralin compounds of formula (I): wherein R, R, R, R, R, R, R, and n are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists

The invention provides aminotetralin compounds of formula (I): wherein R, R, R, R, R, R, R, n, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

Aminotetralin compounds as mu opioid receptor antagonists

This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

Cross-linked glycopeptide-cephalosporin antibiotics

The invention provides novel &#x3b2;adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with &#x3b2;adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

[object Object]

Glycopeptide derivatives and pharmaceutical compositions containing the same

The invention provides novel &#x3b2;adrenergic receptor agonist compounds of formula (I):  wherein R-Rand w have any of the values described in the specification. The invention also provides combinations of such compounds and other therapeutic agents, pharmaceutical compositions comprising such compounds and combinations, methods of using such compounds to treat diseases associated with &#x3b2;adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

This invention provides cross-linked glycopeptide&#x2014;cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

Growing community of inventors

San Francisco, CA, United States of America

Sean Gary Trapp