Motorola Corporation

Sean Gallagher

Huinan J Yu

Barbara M Foley

Wenbin Jiang

Davis H Hartman

Piotr Grodzinski

Xunhu Dai

Jeremy W Burdon

Robert Marrero

Yuk-Tong Chan

Vijay K Nair

Song Q Shi

George N Maracas

Rong-Fong Huang

Vi-En Choong

David Wilcox

Barbara Foley Barenburg

David B Rhine

Thomas J Smekal

Nicholas J Naclerio

Cynthia Ann Gorsuch Briscoe

A microwave device has a monolithic microwave integrated circuit (MMIC) disposed therein for applying microwave radiation to a microfluidic structure, such as a chamber, defined in the device. The microwave radiation from the MMIC is useful for heating samples introduced into the microfluidic structure and for effecting lysis of cells in the samples. Microfabrication techniques allow the fabrication of MMICs that perform heating and cell lysing of samples having volumes in the microliter to picoliter range.

Microfluidic devices with monolithic microwave integrated circuits

A multilayered microfluidic device having a substantially monolithic structure is formed by sintering together a plurality of green-sheet layers. The substantially monolithic structure has an inlet port for receiving fluid, an outlet port for releasing fluid, and an interconnection between the inlet port and the outlet port. The substantially monolithic structure may also include a variety of components to enable useful interaction with the fluid, such as electrically conductive pathways, heaters, fluid sensors, fluid motion transducers, and optically transmissive portions. The components are preferably fabricated using thick-film or green-sheet technology and are preferably co-fired with and sintered to the green-sheet layers to become integral with the substantially monolithic structure.

Integrated multilayered microfludic devices and methods for making the same

This invention relates to apparatus and methods for detecting single base extension to an oligonucleotide array using electrochemical labels.

Electrochemical detection of single base extension

A bio-molecule analyzer includes an array of addressable light sources, a photoconductive layer of material having a layer of electrically conductive material on a surface thereof mounted on the array of addressable light sources, and a plurality of test sites on an opposing surface of the photoconductive layer of material defined by the plurality of light sources. A solution containing a plurality of bio-molecules is positioned in electrical contact with the plurality of test sites. An electrical potential is connected between the solution and the layer of electrically conductive material, whereby the array of addressable light sources emit beams of light through a plurality of portions of the photoconductive layer of material to define the test sites and complete electrical circuits between the layer of electrically conductive material and the solution.

Bio-molecule analyzer with photosensitive material and fabrication

A bio-molecule analyzer including a plurality of test sites on a transparent substrate, each test site having probe molecules attached thereto. An array of addressable light sources are positioned in optical alignment with a corresponding test site. A solution containing sample molecules is positioned in contact with the plurality of test sites. A detector array having a plurality of photodetectors positioned in optical alignment with the array of addressable light sources, one photodetector corresponding to each light source, and a light filter positioned between the detector array and the plurality of test sites for absorbing the light from the light sources and transmitting the light from the test sites to the detector array.

Bio-molecule analyzer with detector array and filter device

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Scottsdale, AZ, United States of America

Sean Gallagher