C. R. Bard, Inc.

W. L. Gore & Associates, Inc.

Nmt Medical, Inc.

Csa Medical, Inc.

United States Endoscopy Group, Inc.

Sean Forde

Richard A Gambale

Michael F Weiser

Stephen J Forcucci

Steven W Opolski

Richard T Choh

David J Callaghan

Carol A Devellian

James J Scutti

Chirag B Shah

Brian M Hanley

Andrzej J Chanduszko

Gary S Falwell

John P O'Connor

Sean A McDermott

Michel Haissaguerre

Stephanie M Kladakis

Donald F Patterson

Todd A Peavey

Erik Glaser

Carol A Ryan

Steve W Opolski

George A Downey

Daniel J Grasso

Thomas I Mulcahey

Eric Glaser

Kellywan Kan

Alexander Paloranta

Sean Arthur Mcdermott

The present disclosure pertains to devices and methods for diagnosis and treatment of biological tissue in which the tissue is accessed by a catheter through a working channel of an endoscope and in which the degree of extension of a distal tip of the catheter beyond a distal tip of the endoscope is controlled.

Catheter extension control

The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices and methods to guide delivery devices and instruments. Exemplary instrument guides, including for endoscopes as delivery devices for cryogen delivery catheters and to guide cryogen decompression tubes as instruments, and methods for use of such instrument guides for use in body lumens at treatment sites, are disclosed.

Devices and methods for guiding instruments

The invention generally relates to devices and methods for treating cardiac tissue, including percutaneous closure of cardiac openings such as a patent foramen ovale (PFO) and obliteration of the cardiac cul-de-sacs. The invention includes a device having at least one elongated member. The elongated member has a first material and a second material interwoven with at least a portion of the first material. The second material is capable of transferring energy to tissue in need of treatment.

Devices and methods for treating cardiac tissue

The over-the-wire interlock attachment/detachment mechanism includes a cylindrical lock receiving section of a small diameter attached to an implantable medical device such as a blood clot filter, a stent, or a septal occluder. This cylindrical lock receiving section has a plurality of spaced, curved cutouts to receive both the guide fingers and contoured locking fingers formed on a cylindrical locking section. The locking fingers are angled outwardly from the cylindrical body of the cylindrical locking section, and are moved inwardly into engagement with the curved cutouts of the cylindrical lock receiving section by a sheath which slides over the cylindrical locking section or other suitable operator.

Over-the-wire interlock attachment/detachment mechanism

The present invention provides a patent foramen ovale (PFO) closure clip. The clips of the present invention include two closure members joined by at least two spaced central connecting members. Each of the at least two spaced central connecting members is attached to each closure member at a location on the periphery of the closure member. The clips are designed such that the at least two central connecting members extend through the inclined PFO tunnel and the two closure members compress the overlapping layers of septal tissue, i.e. septum primum and septum secundum, together to close the PFO tunnel. The clips of the present invention take various forms depending, in part, upon the distribution of force required to close a given PFO. Thus, in some embodiments, the closure members include arcuate peaks. In other embodiments, the closure members include loops. In still other embodiments, the closure members include prongs.

Patent foramen ovale (PFO) closure clips

Devices and techniques for modifying and maintaining a configuration of an occlusion device for the closure of physical anomalies, such as an atrial septal defect, a patent foramen ovale (PFO), and other septal and vascular defects are described. The devices and techniques relate particularly to, but are not limited to, modifying and maintaining a configuration of a PFO occluder made from a polymer tube. The proximal portion of a catch member may be provided with one or more protrusions, or arms, or bump or other raised element for securing the occluder in a partial or fully deployed configuration, either temporarily or permanently.

Catch members for occluder devices

The present invention provides systems and methods for occluding or closing a patent foramen ovale of a patient (PFO). The invention includes a catheter carrying an energy delivery element. The catheter introduces the energy delivery element into the patent foramen ovale of a patient's heart. Once appropriately positioned, the energy delivery element applies energy, such as radiofrequency energy, to the tissues surrounding the patent foramen ovale. The application of energy causes the tissues to join together, occluding the patent foramen ovale. The energy delivery element may be removable or permanently implanted in the patent foramen ovale.

Removable intracardiac RF device

This invention relates to medical devices for manipulating medical implants such as, for example, stents, distal protection filters, and septal occluders in a patient's body, and the methods of use thereof. Generally, a medical device of the invention includes a sleeve and an expandable component joined to the sleeve which transitions between a collapsed configuration and a deployed configuration for capturing a medical implant in a patient's body.

Medical device for manipulation of a medical implant

An apparatus for cutting a suture. In one embodiment the suture cutting apparatus includes a distal cutting end and a proximal control end. The apparatus also includes a first tube defining a lumen, and a second tube located and movable within the lumen of the first tube. The second tube defines a lumen and includes a lever arm pivotably attached at the distal cutting end of the apparatus. The lever arm has a cutting edge that is held away from the longitudinal axis of the second tube when the lever arm is located within the first tube, and is biased toward the longitudinal axis of second tube when the lever arm is outside of the first tube.

Suture sever tube

A medical delivery system for delivering or retrieving a medical implant. In one embodiment, the medical delivery system includes a tube having a lumen; an implant; and a suture releasably joined to the implant, the suture comprising a first end, a second end, and a releasable knot, wherein tension applied to the first end of the suture collapses at least a portion of the implant for introduction into the tubular lumen and tension applied to the second end of the suture releases the implant.

Quick release knot attachment system

The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (). Preferably the therapeutic substance is contained within a pellet form () that is deliverable into the interior of the device () after it has been implanted. In a preferred embodiment the implant device () comprises a flexible coiled spring body, the coils () of which have the proper diameter and spacing to contain the pellet () within the interior of the device () to contact the therapeutic agent. In treatment of ischemic tissue such as that of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device () can help to provide an angiogenic effect. Additionally, the cavity () provided by the interior of the device () permits blood to pool around the pellet () and mix with the therapeutic agent. Several delivery systems have provided for delivering the implant and pellet () sequentially or simultaneously.

Agent delivery systems

The present invention provides anchoring mechanisms for tissue implants. The anchors are integrated as part of the structure of the implant and serve to resist migration of the implant from highly dynamic muscle tissue such as the myocardium of the heart. In implant devices configured as a flexible coil, various attributes of the coil may be altered to increase the anchoring capability of the device. The flexibility of the device may be increased to resist migration by changing the coil filament thickness, pitch or filament material. Alternatively, the end coil may be altered to have a broader cross-sectional profile in engagement with the tissue or may include an anchoring barb. Additionally, methods of implanting a tissue implant device are provided.

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Watertown, MA, United States of America

Sean Forde