Genmark Diagnostics, Inc.

Roche Molecular Systems, Inc.

Siemens Medical Solutions Usa, Inc.

Fenwal, Inc.

Advanced Liquid Logic, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Sean Ford

Jon Faiz Kayyem

Darren S Gray

Jayashankar Srinivasan

Jianzhong Zhang

Hartmuth C Kolb

R Michael Van Dam

Arkadij M Elizarov

Dominic Aiello

Reza Miraghaie

Carroll Edward Ball

Hamed Shadpour

Michael Thomas Nguyen

Lawrence Diener

Jorge Alberto Garces

Nikolas James Hansen

Brian P Murphy

Richard I Brown

Vamsee K Pamula

Vijay Srinivasan

David W Wright

Tyler David Jensen

Mark Joseph Brierton

Scott Corey

Marc N Weasler

Jay Srinivasan

Peter Kroehl

Claudia C Argueta

William Bender

Ken Rusterholz

Bradford Frederick Tieman

David Walter Wright

Brian Murphy

In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.

Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system

This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.

Integrated multiplex target analysis

The present invention provides improved methods that allow accurate monitoring and/or control of temperature changes in a microfluidic environment. An advantage of the present invention is that the temperature can be monitored and/or controlled at any location within a microfluidic device, especially where a preparation step, an amplification step and/or a detection step is performed. The invention further provides improved microfluidic devices for practicing the methods disclosed and claimed herein.

Devices and methods for monitoring and controlling temperature in a microfluidic environment

Biochip cartridge

In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation

The present invention provides compositions and methods directed to an electrode initialization step for the electrochemical treatment of monolayers used in electrochemical detection of target analytes on the surface of a monolayer. Electrode initialization creates a more stable monolayer, and resolves variability within the electrochemical signal detected on the monolayer.

Methods for the electrochemical treatment of self-assembled monolayers

The present disclosure relates generally to systems for processing a unit of whole blood into its components while the unit is still in the centrifuge. The system comprises a container holding whole blood and one or more satellite bags or containers that are installed into a holder, which is then inserted into a bucket of the centrifuge. Tubes interconnect the containers, one or more of which are preferably installed into clamping mechanisms resident in the holder. The holder further preferably includes sensing means, such as optical sensors, to sense the location of the interfaces between the separated layers of the whole blood that result from rotation of the centrifuge.

Blood bag systems for separation of whole blood and methods of use thereof

Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

Portable microfluidic radiosynthesis system for positron emission tomography biomarkers and program code

Microfluidic radiosynthesis system for positron emission tomography biomarkers

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Oceanside, CA, United States of America

Sean Ford