Abbvie Inc.

Sean E Mackey

Ye Huang

Philip R Kym

Valentino J Stella

Peter T Mayer

Eric A Voight

Yanbin Lao

Xiaochun Lou

Christopher P Miller

Brian P Enright

Geoff G Zhang

Mark A Matulenko

Vincent S Chan

Rajkumar V Conjeevaram

Zhi Wang

James Patrick Stambuli

Benoit Cardinal-David

Alexander D Huters

Rodger F Henry

Jeremy Hemingway

Phil D Anderson

Ji Zhou

Martin J Gibler

Russell C Klix

David Andrew Parrott

Christoph L Gillum

Scott Smieja

Kevin Novak

Ted J Hanagan

Gurjinder Dhami

Scott W Krabbe

Dennis Y Lee

Raimundo Ho

Benjamin Greuel

Kenneth E Hogue

Thomas Rebne

Mark A Bennett

Kenneth R Waeber

Kassibla E Dempah

Patrick A Harrell

Bradley A Clark

Alexandru Deac

Randy A Menges

Jayne Zimmerman

James Stambuli

Jeremy L Hemingway

Jim Hoch

Ryan Thompson

Mark Panzer

Raj Conjeevaram

Bradley Clark

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

Methods of treating Parkinson's disease

A syringe containing a high water content product and for use in a drug infusion system is provided. The syringe includes a plunger carrying front and rear o-rings made of a diene rubber compound such as chlorobutyl rubber or bromobutyl rubber to impart very low gas permeability characteristics to the o-rings. The plunger may be molded as a single part or in two parts. If molded as one part with radially-engaging mold portions, the seal glands in the plunger may include parting lines from the mold. If molded as two parts with axially-engaging mold portions, the front seal gland may include a sealing surface and under cut that has no parting line. The o-rings may be surface treated with a lubricant to improve sealing where the molding process gives rise to parting lines in the seal glands.

Sealing arrangement for syringe

Carbidopa and L-dopa prodrugs and methods of use

The present disclosure relates to (a) an improved pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent (b) methods of producing the pharmaceutical composition and (c) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.

Levodopa and carbidopa intestinal gel and methods of use

A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges &#x2212;25&#xb0; C. to 40&#xb0; C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure. A second force lower than the first force is sufficient to overcome the second contact pressure and move the plunger in the second portion to continue dispensing product. The syringe may include a restraining element for accommodating expansion of the product during freezing.

Syringe with two-stage sealing pressure

Growing community of inventors

Grayslake, IL, United States of America

Sean E Mackey