Genevant Sciences Gmbh

Phaserx, Inc.

University of Washington

Sean D Monahan

Mary Gallagher Prieve

Charbel Diab

Michael S DeClue

Pierrot Harvie

Anna Galperin

Debashish Roy

Michael E Houston, Jr

Maher Qabar

Amber E Paschal

Russell N Johnson

Allan Sachs Hoffman

Patrick S Stayton

Anna S Gall

Paul Hickok Johnson

Priyadarsi De

Michael E Houston

Robert W Overell

Amber E E Paschal

Jean-Rene E Ella-Menye

Michael S Declue

Mary G Prieve

Paul H Johnson

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

Branched peg molecules and related compositions and methods

Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. Also disclosed are related compositions and delivery systems.

Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells

Nucleic acid constructs and methods of using the same

Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Multiblock copolymers

Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.

Targeting monomers and polymers having targeting blocks

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Growing community of inventors

Lake Forest Park, WA, United States of America

Sean D Monahan