Cryocath Technologies Inc.

Medtronic Cryocath LP

Axcella Health Inc.

Biosense Webster, Inc.

Other

Halliburton Energy Services, Inc.

Sean Carroll

Dan Wittenberger

Marwan Abboud

Daniel Nahon

Cristian Petre

Steven G Arless

Allan Skanes

Réal Ste-Marie

Alan H Menkis

Fredric L Milder

Jean-Pierre Lalonde

Raffi Afeyan

Benoit Thibault

Mathieu-Philippe Aubert

Domenic N Santoianni

George J Klein

Michael Hamill

William Comb

Philippe Marchand

Robert A Martin

John W Lehmann

Claudia Lueckge

Marc Dubuc

Matthew Russell

Richard Gallo

Marc-André Marcotte

Michael Linley Fripp

Leonilda Capuano

Jennifer Maffre

Claudia L&uuml;ckge

Andrew J Downing

Jean-Pierre LaLonde

Maribeth Esguerra

Frederic L Milder

Tara Zerby

Margaret Yoklavich

Gianluca De Rienzo

Real Ste-Marie

Marc-Andre Marcotte

This disclosure provides pharmaceutical compositions comprising defined amino acid components, and methods for treating traumatic brain injury comprising administering an effective amount of the compositions to a subject in need thereof.

Amino acid compositions and their use for the treatment of traumatic brain injury

This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.

Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting

This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or &#x3b2;-thalassemia).

Compositions and methods for the treatment of hemoglobinopathies and thalassemias

An apparatus for generating electrical power downhole comprises a housing located in a drillstring. A primary flow channel is formed through the housing. At least two secondary flow channels are located in the housing and arc laterally displaced from the primary flow channel, A fluid driven electrical generator is positioned in each of the at least two secondary flow channels. A controllable flow diverter is associated with each of the secondary flow channels to controllably divert at least a portion of a fluid flow m the primary flow channel to at least one of the at least two secondary flow channels to drive the generator therein.

Downhole power generation system

A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation tool is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.

Surgical clamp having treatment elements

A catheter adapted for mapping and ablating epicardial tissue from the pericardial cavity includes a catheter body and an electrode assembly that has a tip section and a loop member lying generally within a plane, wherein the tip section includes an ablation electrode exposed on one side of the loop member and an insulation member exposed on an opposite side of the loop member. The catheter also includes a intermediate section between the catheter body and the electrode assembly, wherein the intermediate deflects the loop member and the tip section bi-directionally within the same plane. So arranged, the catheter can be safely maneuvered in the pericardial sac and swept in a side to side motion over the epicardium with the ablation electrode reliably facing and making contact with the epicardium. The tip section can include a balloon that is inflatable to push away surrounding pericardial tissue. The catheter may further include an injection needle whose distal end can extend outside of the tip section to puncture epicardial tissue. A lumen in the injection needle allows for delivery to agents directly to the punctured tissue and thermocouple wires can be carried in the lumen for temperature sensing at the treatment site.

Epicardial mapping and ablation catheter

A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.

Method of simultaneously freezing and heating tissue for ablation

Catheter with cryogenic and electrical heating ablation

A method for puncturing a proximal membrane without puncturing a second, distal membrane is provided. The method comprises distally advancing an elongated body through an elongated tubular member to a first position where a distal end of the elongated body is in a first configuration. In the first configuration, the distal end of the elongated body is positioned outside the distal end of the elongated tubular member. The distal end of the elongated body has a distal tip, in this first configuration, that is sufficiently rigid and sharp to puncture the first, proximal membrane. From this first configuration, the distal tip of the elongated body is slightly advanced puncture the first, proximal membrane. After puncturing the first, proximal membrane, the elongated body is advanced through the punctured proximal membrane whereby the distal tip of the elongated body moves into a second configuration. In the second configuration, the distal tip of the elongated body curves into a j-shape, forming a blunt distal surface facing the second, distal membrane.

Safe septal needle and method for its use

A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.

Surgical clamp having trasmurality assessment capabilities

Deflection mechanisms are disclosed that are positionable to deflecting portions of a flexible body, such as a catheter, in more than one direction in a single plane, as well as in more than one plane. The invention allows a distal portion of a catheter to be deflected more than 360 degrees to provide a loop.

Defined deflection structure

Surgical clamp having transmurality assessment capabilities

A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles.

Growing community of inventors

Rancho Cucamonga, CA, United States of America

Sean Carroll