Amazon Technologies, Inc.

University of Washington

Sean C Murphy

Bradley C Stone

Gurunandan Krishnan Gorumkonda

Onkar Jayant Dabeer

Jungtao Liu

Toby Ge Xu

David L Alspaugh

Sachin Rajendra Kothari

Stephanie Tomasetta

Durgaprasad Kashinath Shamain

Celalettin Umit Bas

Trudy Parnell

Jason Dwayne Thomas

Robert Theodore Cassidy

Sian Leng Lee Chew

Christopher Cudney

Brad Stone

Mark Stankiewicz

Matthew Wilkie

Zachary Tokarczyk

An immunogenic composition is provided herein. The immunogenic compositions are used to identify and select immunogenic antigens that elicit immune responses in a subject and may be subsequently used in multi-antigen vaccine compositions against one or more diseases or conditions. According to some embodiments, the immunogenic composition may include a plurality of nucleic acid fragments or minigenes derived from a nucleic acid library, wherein each nucleic acid fragment encodes a different antigen or functional portion thereof, and wherein the different antigens or functional portions thereof are associated with one or more disease or condition. The immunogenic composition may also include a delivery medium loaded with the plurality of nucleic acid fragments and in some embodiments, the delivery medium is loaded with nucleic acid fragments in such a way that individual antigen presenting cells receive only a subset of the nucleic acids within a vaccine in order to minimize antigenic competition.

Immunogenic compositions, antigen screening methods, and methods of generating immune responses

In one aspect, the present disclosure provides a trapping vaccine composition comprising a trapping antigenic component, a protective component, and a liver cell-targeting component, wherein the trapping antigenic component comprises a nucleic acid molecule or a protein, the protective component comprises a synthetic or non-natural molecule or formation of synthetic or non-natural molecules, and wherein the liver cell-targeting component is capable of delivering the vaccine composition to a liver cell or liver tissue. The present disclosure additional provides vaccination methods comprising (i) administering a priming composition comprising a priming antigenic component or a first dose comprising the priming composition to the mammal; and (ii) administering a trapping composition comprising a trapping antigenic component, a protective component, and a liver cell-targeting component, or a second dose comprising the second composition to the mammal, wherein the priming and trapping compositions or doses are not administered concurrently and wherein the number of resident memory T cells in the liver are increased following administration of the trapping composition. In certain embodiments, vaccine compositions and regimes are provided that protect against liver-tropic pathogens, e.g., a malarial infection. In an embodiment, a vaccine composition and regimen are provided that protect against an infection caused byorsporozoites.

Targeted vaccination in the liver

Systems and methods are disclosed to secure rollable carts to sortation systems. In one embodiment, an example system may include a first chute configured to guide packages to a first moveable cart that is disposed at a first end of the first chute, and a first anti-tip mechanism configured to prevent tipping of the first moveable cart. The first anti-tip mechanism may include a frame, a first C-shaped component coupled to the frame, and a second C-shaped component coupled to the frame. The first C-shaped component may be configured to engage a first portion of the first moveable cart, and the second C-shaped component may be configured to engage a second portion of the first moveable cart, such that the first moveable cart is prevented from vertical movement.

Systems and methods to secure rollable carts to sortation systems

Embodiments herein describe a scanning station for identifying an air gap between one or more items stored in a container (e.g., a cardboard box) and a surface of the container (e.g., a top lid of the cardboard box). After identifying the air gap, in one embodiment, the scanning station provides instructions to a downstream cutting station where the container is cut opened. In one embodiment, the scanning station includes one or more articulating arms that each includes a scanner (e.g., a radar sensor) attached on an end of the articulating arm facing the container. Moving the articulating arms along the boundaries of the container provides a 3D image of the inside of the container. By processing this image, the scanning station can identify an air gap along a desired cut line as well as a thickness of the sides of the container.

Radar based guidance system perceiving contents of a container

Systems and methods to manipulate objects may include an adjustable robotic end of arm tool including a pair of static forks or arms and a pair of movable forks or arms. The static forks may be configured to lift objects, such as pallets, totes, or bins. The movable forks may be configured to move between a plurality of positions, including a storage position and a lifting position. When in the lifting position, the movable forks may also be configured to lift objects, such as pallets, totes, or bins, such that the adjustable robotic end of arm tool may simultaneously or concurrently lift and manipulate multiple objects using the static forks and the movable forks, thereby improving speed and efficiency of operations or processes utilizing the adjustable robotic end of arm tool.

Adjustable robotic end of arm tool for multiple object handling

A manipulator can includes a frame, a first deployable support element configured to extend or retract with respect to the frame when acted on by an actuator, a static support element fixedly connected with the frame and comprising a second set of retention elements, and any suitable number of additional deployable support elements. Each support element can further include a respective set of retention elements configured to retain an item. In use, a manipulator can be used to move items by identifying an item contact area of an item to be moved, selectively deploying or retracting the deployable support elements based on the item contact area, and then contacting and retaining the item with the retention elements of the selected support elements.

Robotic item handling using a variable area manipulator

An end-of-arm-tool (EOAT) can elongate from a retracted position into an extend position to be configured to fit within a space available for contacting and grasping an object. The EOAT includes arrays of linkage elements having corresponding arrays of suction cups attached to linkage element of the linkage element array. In the retracted position, the arrays are pulled away from the distal end of the EOAT to be alongside of a longitudinal rail. In the extended position, a proximal end of the array is moved toward the distal end of the EOAT such that the linkages glide outwardly and linearly to deploy additional suction cups of the suction cup array against the object-to-be-lifted.

Flexible end of arm tool

Method and apparatus for optimizing control of robotic systems. Failures of a robotic device performing a lifting operation for one or more items within a fulfillment center over a window of time are monitored. Responsive to the failures exceeding a predefined threshold number of failures for the window of time, one or more control operations for optimizing performance of the robotic device are determined, by processing environmental metrics, failure type, mode of operation and item type information as inputs to a trained machine learning model. A control system for the robotic device is configured based on the determined one or more control operations, and movement of the robotic device is controlled using the configured control system, to perform the lifting operation for one or more additional items within the fulfillment center.

Adaptive perception for industrial robotic systems

A conveyor system includes a belt wound around a roller assembly along a belt axis. The belt is configured to convey objects along the roller assembly in a direction of conveyance. The belt includes a primary belt portion that is in contact with rollers of the roller assembly and defines the belt axis. The conveyor includes an actuator configured to cause the belt to selectively define at least one belt peak that protrudes from the primary belt portion at a peak height measured orthogonally from the belt axis.

Growing community of inventors

Seattle, WA, United States of America

Sean C Murphy