Bluefin Biomedicine, Inc.

Cell Signaling Technology, Inc.

Sean Andre Beausoleil

Nels Eric Pederson

Scott Michael Lonning

Tinglei Gu

Klarisa Rikova

Roberto Polakiewicz

John Edward Rush, Ii

Aleksandr Tkachev

Jason G Beaudet

Wan Cheung Cheung

Daniel Mulhern

Disclosed herein are anti-lymphocyte antigen 6 complex, locus H (LY6H) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Anti-LY6H antibodies and antibody drug conjugates

Disclosed herein are Interleukin 1 Receptor Accessory Protein (IL1RAP) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.

Anti-IL1RAP antibodies and antibody drug conjugates

In some embodiments, the invention relates to methods for creating a monoclonal antibody that specifically binds to antigen. The method may start from a polyclonal population of antibodies such as a non-specific polyclonal population or a polyclonal population of antibodies that specifically bind to the antigen. The method includes obtaining nucleic acid molecules encoding heavy and light immunoglobulin chains (or variable regions thereof) of multiple immunoglobulins from an animal; obtaining mass spectra information of peptide fragments of a population of polyclonal immunoglobulins that specifically bind to an antigen of choice; comparing and/or correlating the mass spectra information of the peptide fragments of the polyclonal immunoglobulins with predicted mass spectra information of predicted amino acid sequences encoded by the nucleic acid molecules, and then assembling the heavy and light chains to create an antibody (or variable region thereof) that specifically binds to the antigen.

Methods and reagents for creating monoclonal antibodies

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Essex, MA, United States of America

Sean Andre Beausoleil