Vaxinnate Corporation

Scott W Umlauf

Thomas J Powell

Langzhou Song

Lynda G Tussey

Ge Liu

Yi Zhang

Alan R Shaw

Robert S Becker

Hong Li

Uma Kavita

Xiangyu Liu

Bruce Weaver

Lynda Tussey

Compositions that include at least a portion of a flagellin and an antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to infection.

Deletion mutants of flagellin and methods of use

Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one viral antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.

Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin.

Fusion proteins and methods of use

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Cranbury, NJ, United States of America

Scott W Umlauf