Nxstage Medical, Inc.

Transmedics, Inc.

New Power Concepts LLC

Siemens Medical Electronics, Inc.

Siemens Medical Systems, Inc.

Draeger Medical Systems, Inc.

Scott W Newell

Dennis M Treu

James M Brugger

Jeffrey H Burbank

William J Schnell

Jerome James

Waleed H Hassanein

William K Weigel

Stanley Kyi

Robert Fishman

Tamer I Khayal

Richard Bringham

Joseph E Turk, Jr

Goetz Friederichs

Mark T Wyeth

Kenneth Everett Buckler

David Desouza

Daniel Joseph Rubery, Jr

Garrett Casey

John Sullivan

Robert Havener

Mark Anderson

Ihab Abdel Fattah

Steven A White

Anas Abdelazim

Matthew De Remer

Michael Van Driel

Paul Murray

Doug Harriott

Ron Taylor

Orlando Soto

Ronald Taylor

Burt Ochs

Robert Havner

Tom Bishop

Thomas H Bishop

Christopher Charles Langenfeld

Dmitri Menn

Jonathan M Rourke

Clifford Mark Kelly

Yakov Kogan

Giovanni Cecere

Hossam Algamil

Larry Goff

Keith David J Wheeler

Andrew A Schnellinger

Michael G Norris

David M Carpenter

Ahmed Elbetanony

Paul Lezberg

Dennis Sousa

Tomas Russ

John Rourke

Amanda Wozniak

Jeffrey D Renk

Eric Jensen

Joseph Rausa

Lawrence Goff

Thomas S Schnellinger

Thomas K Naylor

James M Chickering

Steve A White

Keith J Wheeler

Steve White

Hoss Algamil

Daniel J Rubery

Jeffrey Renk

A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.

Medicament preparation and treatment devices, methods, and systems

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Systems and methods for ex vivo lung care

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Flow balancing devices, methods, and systems

A patient's body temperature measurement may be made by varying the heat transfer dynamics of a fluid exiting the patient's body and fitting parameters of heat transfer configuration to measurements under the varied conditions. Then the input temperature of the patient core can be extracted from the model and a current temperature measurement remote from the patient core and optionally other measurements such as fluid flow rate.

Body temperature measurement devices, methods, and systems

A method for measuring pressure includes securing a flow channel to a chassis of a measurement device, the flow channel having a flexible wall with a first mechanical engagement feature presented from an external surface thereof. The method also includes engaging the mechanical engagement feature with a complementary engagement member connected to a force transducer, the securing being effective to immobilize the flow channel relative to the force transducer, and detecting at least one of the position and orientation of the of the flow channel relative to transducer and comparing to at least one of a predefined position and orientation. Further, the method includes generating a signal responsive to the detecting, flowing a fluid through the flow channel, and transmitting forces caused by displacement of the flexible wall through the complementary engagement member to the force transducer. Further, electrical signals are generated responsively to a state of the force transducer.

Pressure measurement devices, methods, and systems

A medicament preparation system includes a disposable cartridge with a flow path. Various sensors may be placed on the cartridge to measure qualities of the fluid flowing through the flow path. The sensors are placed in precise locations using various approaches that make manufacturing of the cartridge efficient and repeatable. A drain line that is susceptible to fouling may be preattached and various approaches are used to remove or reduce the fouling. An elastomeric contact can also be present in the medical preparation system and used in a conductivity measurement subsystem.

Fluid management and measurement systems, devices, and methods

A system for measuring electrical conductivity includes a fluid conduction measuring circuit and a temperature measuring element having at least one thermal contact portion with a temperature sensor and a temperature measuring circuit. A controller is configured to control the conduction measuring circuit and the temperature measuring element. A fluid circuit is configured to carry a fluid and has a wetted conductor inside a conductivity cell portion, the wetted conductor having a contact, external to the fluid circuit, for interfacing with the fluid conduction measuring circuit. Further, at least one temperature measurement portion has predefined thermal properties and is configured to touch the thermal contact portion. The controller controls the temperature measuring element and the conduction measuring circuit to generate and output at least one set of contemporaneous temperature and conduction measurements.

Fluid property measurement devices, methods, and systems

A method of controlling flow through a flexible tube includes providing a pinch clamp mechanism including a pinching element and a pinching surface configured to apply a force on the flexible tube when the flexible tube is positioned between the pinching element and the pinching surface. The method also includes displacing the pinching element relative to the pinching surface with a mechanical drive unit and biasing the pinching element toward the pinching surface with a spring.

Pinch clamp devices, methods, and systems

A low leakage current fluid heater and systems and methods thereof. The fluid heater has a configuration whereby a heating element is isolated from a fluid channel so as to leak into fluid passing through the channel an allowed amount of leakage current. Fluid passing through the fluid heater can be heated to a desired temperature. A controller can provide control signals to driver the fluid heater to the desired temperature and maintain the temperature at the desired temperature.

Fluid heating apparatuses, systems, and methods

A conductivity measurement device includes first and second conductivity measurement flow channels positioned in a fluid circuit and fluidly linked for fluid flow between the first and second conductivity measurement flow channels. A controller having a current source connected to the first and second conductivity channels applies alternating voltages at frequencies that are different, each being respective to one of the first and second conductivity cells.

Treatment fluid devices methods and systems

A pressure measurement pod for use in blood circuits includes a pressure sensing pod defining a chamber and having a rigid wall portion and an integral flexible wall portion forming a flexible, moveable, fluid-impermeable diaphragm with a first major side thereof facing an interior of the chamber and a second major side opposite the first major side. The second major side faces outwardly away from the chamber, and the pod has ports on sides of the chamber. The internal surfaces of the chamber and ports are shaped such that any contour following the internal surfaces to the outside of one of the ports traces only surfaces characterized by positive or neutral draft angles such that invasive mold portions may be withdrawn through the ports thereby permitting the pressure measurement pod to be molded in a single shot molding process.

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Ipswich, MA, United States of America

Scott W Newell