University of Michigan

The Brigham and Women's Hospital, Inc.

Strata Oncology, Inc.

Scott Tomlins

Arul M Chinnaiyan

Mark A Rubin

Francesca Demichelis

Daniel Rhodes

Rohit Mehra

Sven Perner

Charles Lee

Xiao-Wei Sun

Saravana Mohan Dhanasekaran

Dan Rhodes

Bryan Johnson

Arul Chinnaiyan

Embodiments of a method and/or system (e.g., for microsatellite instability detection associated with at least one cancer condition; etc.) can include: determining a microsatellite-related background model; determining one or more loci associated with microsatellite instability based on the microsatellite-related background model; and/or determining a microsatellite instability characterization (e.g., a binary status determination between microsatellite instability such as MSI-H, and microsatellite stability such as MSS; etc.) for the user. Additionally or alternatively, embodiments of the method and/or system can include facilitating treatment provision for one or more users based on the microsatellite instability characterization.

Microsatellite instability characterization

Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.

Recurrent gene fusions in prostate cancer

Compositions and methods associated with recurrent MIPOL1-ETV1 genetic rearrangements that are useful for cancer diagnosis and therapy are disclosed.

MIPOL1-ETV1 gene rearrangements

Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.

Growing community of inventors

Ann Arbor, MI, United States of America

Scott Tomlins