Pacesetter, Inc.

Scott Salys

Gene A Bornzin

Yougandh Chitre

Kevin L Morgan

Sheldon Williams

Andrew W McGarvey

Kerwyn Schimke

Jnyan Patel

Mark W Kroll

Xiaoyi Min

Michael Xiaoxuan Yang

John R Helland

Guy P Vanney

Phong D Doan

Eric Falkenberg

Keith Victorine

J Christopher Moulder

Annapurna Karicherla

Dorab N Sethna

Christopher J Fleck

Timothy Cox

Ravi Jain

Thao T Ngo

Elizabeth Nee

Peter Fong

Ravisankar Gurusamy

Chris Parrillo

Matt Phillips

Luz Padilla

A method of manufacturing an implantable lead includes providing a core including at least one longitudinal lumen; providing a jacket comprising a reflowable material; positioning the core at least partially within the jacket; and, after positioning, applying heat to cause the material of the jacket to reflow and bond to the core. An implantable lead includes a core including at least one longitudinal lumen; and a jacket comprising a reflowable material. The core may be at least partially disposed within the jacket with the material of the jacket reflow-bonded to the core. The implantable lead may further include at least one lead component associated with at least one of the core and the jacket.

Implantable lead and method of making the same

Disclose herein is a method of measuring pressures in a coronary sinus. In one embodiment, the method includes: introducing a distal portion of a lead or tool into the coronary sinus, wherein the distal portion includes first and second pressure sensors and at least one selectably expandable member; expanding the at least one expandable member such that the first and second sensors are isolated from each other within the coronary sinus; and taking pressure measurements with the first and second sensors when isolated from each other.

Coronary venous system pressure sensing

An implantable stimulation system includes a stimulation current generator encased in an implantable housing, one or more stimulation leads to deliver therapeutic stimulation from the generator to target patient tissue, and inductive elements arranged to condition the stimulation for delivery to the target tissue with increased efficiency and reduced pain sensation. The inductive elements are arranged external to the housing and integral with one or more of a stimulation lead or an external component of the housing, such as a header. The inductive elements serve to condition therapeutic stimulations such that varying the output of the generator allows the system to deliver arbitrary effective waveforms to the target tissue.

System to create arbitrary waveforms using an external inductor and an implantable medical device

A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.

Subcutaneous implantable cardiac device system with low defibrillation thresholds and improved sensing

A body implantable lead system includes an over-the-wire lead with a longitudinally extending lumen. A hollow stylet having an outer peripheral surface is introduced into the lumen and an annular resilient blood seal within the lumen may be sealingly positioned between the outer peripheral surface of the stylet and the lead to prevent flow of blood beyond the blood seal and into the lumen in a proximal direction. A guidewire is slidably received within the hollow stylet and includes a tip end which may project through the passage at the distal end of the lead such that relative movement of the guidewire and stylet within the lead is enabled while avoiding friction between the blood seal and the guidewire. Either the guidewire or the stylet may be preshaped for proper placement of the lead for engagement with the body tissue and surrounded by a semi-rigid retractable sheath.

Deflectable hollow stylet guidewire system

An implantable multi-conductor endocardial lead for a cardiac stimulator includes a tubular lead body of flexible resilient insulative material having a first lumen and a smaller diameter tubular member of similar material having a second lumen is coaxially received in the first lumen. An outer coil conductor is received within an annular cavity between the tubular lead body and the tubular member. An elongated inner coil conductor is received within the second lumen. A tip electrode at the distal end of the lead is coupled to the inner coil conductor and a ring electrode proximally spaced from the tip electrode is coupled to the outer coil conductor. All components except for the outer coil conductor have a normally straight configuration and the outer coil conductor is pre-shaped into a generally circular looped configuration such that, upon assembly, the resulting endocardial lead results in a J-configuration at its distal end.

Method of manufacturing an implantable J-shaped lead

An implantable lead having an elongated lead body that includes an electrical conductor extending between a distal end of the lead body and a proximal end of the lead body is disclosed. The lead further includes an electrode formed at the distal end of the lead body, the electrode being coupled to the electrical conductor and one or more passive fixation mesh sections coupled to the distal end of the lead body that promotes tissue over growth.

Passive fixation mechanism for epicardial sensing and stimulation lead placed through pericardial access

An implantable myocardial stimulation lead comprises a lead body having a distal end and a proximal end, and an electrical connector carried by the proximal end of the lead body. An electrode header carried by the distal end of the lead body has an axis and includes a helical fixation element extending along the axis, the electrode header having a surface configured to receive a driver for rotating the electrode header to screw the helical fixation element into the tissue of the heart. The lead body carries along its length a strain relief member resisting excessive bending of the lead body.

Myocardial lead and lead system

An implantable cardiac stimulation device is equipped with an isolation system capable of attenuating or eliminating induction currents flowing through the stimulation device by eliminating induction loops. The isolation system comprises a magnetic insulator configured to shield selected components of the stimulation device from external magnetic fields or radio-frequency (RF) signals. The magnetic insulator comprises a plurality of sensors that are configured to detect the intensity of the external magnetic fields and/or RF signals, and a switch bank that electrically isolates certain components of the stimulation device to eliminate the induction loops. The isolation system further comprises an attenuation system comprised of at least one magnetoresistor disposed along potential induction loops to attenuate induction currents when subjected to undesirable external magnetic fields and/or RF signals.

Implantable stimulation device with isolating system for minimizing magnetic induction

An implantable lead adapted to transmit electrical signals between a connector assembly on a proximal end of the lead and at least one electrode carried by a distal end of the lead comprises a helical fixation element extendable and retractable from the distal end of the lead, the header comprising (a) an inner header part comprising an electrically conductive material that is substantially transparent fluoroscopically, the inner header part having a distal end, (b) an outer header part comprising an electrically insulating material, and (c) a collar attached to the distal end of the inner header part. The collar comprises a material that is substantially opaque fluoroscopically. The collar may be electrically conductive, and electrically and mechanically connected, preferably by means of an overlap joint, to the distal end of the inner header part. The conductive collar thus may be electrically connected to an electrical contact on the connector assembly via the electrically conductive inner header part, whereby the collar may be used for mapping the electrical activity of local body tissue. Alternatively, the collar may be electrically isolated by, for example, covering the outer surface of the collar with an electrically insulating layer.

Active fixation lead with multiple density

An implantable lead for transmitting electrical signals between a proximal end and a distal end comprises an elongated lead body defining a longitudinally-extending lumen, and a plurality of individual electrical conductors contained in the lumen of the lead body and extending between the proximal and distal ends, the plurality of individual conductors sharing a common insulating coating. Each of the plurality of individual electrical conductors preferably comprises a braided, multifilar cable conductor. In one embodiment, the common insulating coating electrically isolates the plurality of conductors from each other, and may include a bridging portion extending between individual conductors. The plurality of electrical conductors and the common insulating coating comprise a conductor assembly that may have a helical configuration defining a longitudinally-extending passageway for receiving a stylet, guide wire, or the like, for placement of the distal end of the lead. Alternatively, the conductor assembly may have a tubular configuration, the plurality of individual conductors being embedded therein in spaced-apart, parallel relationship or along a generally helical path along the length of the lead body for greater lead flexibility.

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Los Angeles, CA, United States of America

Scott Salys