Bioanalytical Systems, Inc.

Scott R Peters

James M Hampsch

Candice B Kissinger

Curtis E Bohs

Donnie A Evans

Jonathan D Combs

W Gamini Gunaratna

Patrick D Mullen

William J Schmidt

A method for the storage of biological samples is disclosed. The method includes the steps of coupling a storage device to a biological sample collection apparatus capable of collecting a biological sample from a subject, introducing a biological sample from the biological sample collection apparatus to the storage device, and drying the biological sample on the storage device. In another embodiment, the storage device used by the method may include a collection medium having a top surface, a bottom surface, and a predetermined size and shape, the top surface comprising a position marker and at least one binding site operable to bind a biological sample; and a protective facing substantially impermeable to the biological sample, the protective facing coupled to the top surface of the collection medium and having a size and shape substantially similar to the predetermined size and shape of the collection medium.

Devices, systems, and methods for the collection of body fluids

A tube assembly, system and method for biological sample collection. In one embodiment, the tube assembly of the present disclosure includes a first tube, a second tube, a mechanism for securing the first and second tubes. The securing mechanism orients the first ends of the first and second tubes in a manner such that the first end of the second tube extends beyond the first end of the first tube to create an interstitial space between the outer diameter of the first tube and the inner diameter of the second tube.

Systems and methods for sample collection

Devices, systems, and methods for the collection of biological samples. In at least one exemplary embodiment, a device comprises a collection medium having top and bottom surfaces and a predetermined size and shape, the top surface comprising a position marker and at least one binding site operable to bind a biological sample, a protective facing substantially impermeable to the biological sample, the protective facing coupled to the top surface of the collection medium and having a size and shape substantially similar to the predetermined size and shape of the collection medium. The protective facing being sized and shaped to define a first void positioned to allow for the transfer of the biological sample through the protective facing and onto the at least one binding site of the collection medium, and a second void positioned to expose the position marker for alignment of the collection medium.

A device, system, and method for labeling three-dimensional objects. A sheet comprising at least one tag, each tag consisting of a thin piece of resilient, print-treated polyester, or other material, and a method of attaching the tag to a three-dimensional object, such as a glass or plastic vial, is described. The tag identifies each individual object, and permits transfer of the object throughout a series of analytical processes without losing object identity. The tag is marked by offset printing, laser engraving, or another marking process such that the marking does not become unreadable during handling and testing. Labeling of individual objects is accomplished by inserting an object through an aperture in the tag resulting in the tag being attached to the vial. Removal of the vial from the sheet causes the tag to be separated from the sheet and to remain attached to the vial. Alternatively, a sheet holder, such as a rack, could be used to hold the sheet of tags during the labeling process. Labeling three-dimensional objects through the use of the device, system, and method of the present invention is faster, easier, and less expensive than current labeling methods. Additionally, the engagement of the tag to the three-dimensional object withstands extreme temperature changes better than the adhesive attachment of other labels, and the tags are easier to remove than adhesive labels.

Device, system and method for labeling three-dimensional objects

A movement-responsive system for conducting tests on freely-moving animals is disclosed. The invention includes a container for housing the animal, a mechanism for rotating the container in response to rotational movement of the animal, and one or more test leads connected to the animal for performance of biomedical tests such as infusion, in vivo ultrafiltration, laser-doppler monitoring of blood flow, electrical stimulation and in vivo microdialysis, and a method for automated micro sampling of body fluids in free-moving animals. Because the cage is rotated in response to the animal's rotational movement, no swivel connectors are needed. A rotational sensor assembly is provided to detect rotational movement of the animal within the container. A vertical sensor assembly is mounted to the counterbalanced arm for monitoring vertical movements of the animal. The outputs of the sensor assemblies are routed to a computer or other device for monitoring and/or analyzing the activity of the animal. The container is configured to act as an operant chamber or a metabolic chamber by locating a hole in the bottom of the container and through the rotating mechanism. The invention also enables a new method for sampling body fluids of the animal without restricting the animal's movements. The sampling method uses a syringe pump to result in high fidelity fluid control greatly increasing repeatability of experiments. Further, the method employs pinch valves to control fluid flow in conjunction with an anticoagulant coated tubing, thereby resulting in a blood sampling method that does not require the use of heparinized sterile saline solution as a wash fluid.

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West Lafayette, IN, United States of America

Scott R Peters