Incyte Pharmaceuticals, Inc.

Proofpoint, Inc.

Incyte Genomics, Inc.

Scott R Panzer

Jeffrey J Seilhamer

Gary B Zweiger

Mary Jane Cunningham

Yanyan Yang

Greg Wittel

Steven Lewis

Preeti G Lal

Henry Yue

Mariah R Baughn

Ingrid E Akerblom

Matthew R Kaser

Yalda Azimzai

Tod M Klingler

Laura Y Ito

Brian M McKelligon

David M Hodgson

Landes C Wong

Helen E Jolley

Mayank K Thanawala

Richard Cathcart

Andrew D Ament

Stephen E Lincoln

A system and method are described for using different types of image fingerprints to detect spam. Specifically, one embodiment of the invention dynamically calculates both an image-specific signature (e.g., MD5 checksum) and a generic signature for each image and, if a specified number of images have the same generic signature but different image-specific signatures, then a feature is fired within a spam engine to indicate that the images are spam. By way of example, a computer-implemented method is described for detecting spam images within a stream of messages comprising: generating generic signatures and image-specific signatures for images within the stream of messages; determining if two or more images with matching generic signatures have different image-specific signatures; and updating a spam filtering engine to include the matching generic signatures if the number of images with matching generic signatures but different image-specific signatures reach a specified threshold value.

Apparatus and method for performing spam detection and filtering using an image history table

A system and method are described for performing a correlative statistical analysis on a stream of email messages to identify new spam campaigns. For example, a method according to one embodiment of the invention comprises: extracting a series of patterns from a stream of incoming email messages; performing a correlation between the patterns to identify recurring patterns within the stream of email messages over a specified time period; dynamically updating a spam filtering engine to include a particular recurring pattern if the number of times the particular recurring pattern is detected within the specified time period is above a first specified threshold value.

Message stream analysis for spam detection and filtering

The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.

Relational database and system for storing information relating to biomolecular sequences and reagents

The present invention relates to a composition comprising a plurality of polynucleotide targets. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutic treatments for toxicological responses.

Toxicological response markers

The present invention relates to mammalian nucleic acid and protein molecules comprising a plurality of nucleic acid and protein molecules. The mammalian nucleic acid molecules can be used as hybridizable array elements in a microarray in diagnostic and therapeutic applications including detecting metabolic and toxicological responses, and in monitoring drug mechanism of action. The protein molecules can be used in a pharmaceutical composition. The present invention also relates to methods for screening compounds and therapeutics for metabolic responses indicative of a toxic compound or molecule.

Mammalian toxicological response markers

Markers for peroxisomal proliferators

Monitoring toxicological responses

Growing community of inventors

Sunnyvale, CA, United States of America

Scott R Panzer