Pion Inc.

Scott P Jennings

Deren J Dohoda

Konstantin L Tsinman

Dan Tang

Ajit S Narang

David A Kwajewski

Neil Mathias

Michael G Kelly

An apparatus for the combined assessment of dissolution and permeability relies on a receiver chamber that is contained within a donor chamber. A membrane is provided between the two chambers. Measurements can be taken to determine solute amounts of a drug introduced in the donor chamber and amounts of permeated solute in the receiver chamber. Also described are techniques for the assessment of a dissolution rate and total amount of dissolved compound, together with their effect on absorption potential of a compound or a compound product as well as approaches for evaluating in vivo relevant differences between formulations of a compound through their effect on the absorption potential of the compound.

Apparatus and method for the assessment of concentration profiling and permeability rates

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Bridgewater, NJ, United States of America

Scott P Jennings