Mayo Foundation for Medical Education and Research

Oregon Health & Science University

Miromatrix Medical Inc.

Scott Nyberg

Jeffrey L Ross

Markus Grompe

Stephen M Corner

Anne Young

Bruce Amiot

Joseph Lillegard

Allie Haarstad

Raymond Hickey

Jeffrey Ross

The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.

Use of resected liver serum for whole liver-engineering

This document provides bioartificial liver (BAL) devices. Methods for making and using BAL devices also are provided.

Bioartificial liver

A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes.

Bioartificial liver system

Described herein is the generation of Fahheterozygote pigs by homologous recombination and somatic cell nuclear transfer, and a method for producing Fahhomozygote pigs. The Fah-deficient pigs of the disclosure can be used for a variety of research and therapeutic purposes, such as for the expansion of human hepatocytes, and as large animal models of hereditary tyrosinemia type 1, cirrhosis and hepatocellular carcinoma.

Fumarylacetoacetate hydrolase (Fah)-deficient pigs and uses thereof

Fumarylacetoacetate hydrolase (fah)-deficient pigs and uses thereof

Method for treating blood or plasma using hepatocyte spheroids

Growing community of inventors

Rochester, MN, United States of America

Scott Nyberg