Astrazeneca Ab

Scott Nathan Mlynarski

Maurice Raymond Verschoyle Finlay

Iain Simpson

Sameer Pralhad Kawatkar

Tyler Grebe

Dedong Wu

Steve Cook

Jianyan Wang

Disclosed are compounds of formula (Ib) or (Vc), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ib) or (Vc) and methods of using the same for treating cancer, respiratory inflammatory disease, and inhibiting arginase; wherein Ris —H or —C(O)CH(R)NHR; and Ris selected from —H, —(C-C) alkyl and CHOR; Ris —H; or alternatively, Rand R, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and Ris H or —CH.

Arginase inhibitors and methods of use thereof

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein

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Waltham, MA, United States of America

Scott Nathan Mlynarski