Neurogen Corporation

Scott Michael Capitosti

Bertrand Leo Chenard

Rajagopal Bakthavatchalam

Jianjun Xu

Charles A Blum

Manuka Ghosh

Kevin J Hodgetts

Timothy M Caldwell

2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

2-phenoxy pyrimidinone analogues

Substituted biaryl quinolin-4-ylamine analogues of Formula I are provided.  Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Substituted biaryl quinolin-4-ylamine analogues

Growing community of inventors

Middletown, CT, United States of America

Scott Michael Capitosti