Rmb Products, Inc.

Merck Sharp + Dohme Corp.

Scott McFeaters

Jeff Johnson

Bart Carter

Dan Elliott

Riccardo J Tresso

Jason Davidson

Alejandro Llamas

Craig Jack

Anthony Flammino

Scott Eickhoff

Mark A Petrich

Joseph W Locurcio

Matthew H Flamm

Jeffrey Charles Johnson

Mark Anton Petrich

John H Roosa, Jr

Robert Ian Alpern

Dan Elliot

Container system and method for freezing (and subsequently thawing) a liquid such as a drug substance, such that all containers in a set have a uniform width, hence uniform freeze-path length, in the widthwise direction and perpendicular to major walls of the containers, irrespective of the particular length, height, and volumetric capacity of the various containers in the set. This leads to uniform freezing performance and thereby reduces cryoconcentration. The system also eliminates or reduces ice-bridging, and the potential for containers rupturing during freezing and thawing operations.

Container system and method for freezing and thawing a liquid product

The phase-change accommodating rigid fluid container disclosed herein includes a variety of features that protect the container from phase changes of a fluid stored therein. As a result, the container may be in direct contact with the fluid without any flexible membrane or bag there between. For example, the fluid container may include one or more of matched pairs of recesses for physical manipulation of the container, stiffening ribs extending between the recesses, and input/output assemblies acting as inputs for fluid into the container, outputs of fluid from the container, and vents for pressure equalization of the container.

Fluid container with input/output shroud

Phase-change accommodating rigid fluid container

Growing community of inventors

West Point, PA, United States of America

Scott McFeaters