Wyeth

Ortho-mcneil Pharmaceutical Corp.

Wyeth Holdings Corporation

Scott Mason Duncan

Sylvain Daigneault

Warren Chew

Silvio Iera

John Leo Considine

Augustine Tobi Osuma

Michel Bernatchez

Middleton Brawner Floyd

Jianxin Ren

John E Mills

Joachim Ernst Berkner

Miguel Angel Pagan

Jiaxin Ren

Jiaxen Ren

This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.

Antineoplastic combinations

The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.

Process for the synthesis of N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids

Process for the synthesis of N-nacyl-2-amino-4-alkoxy-5-nitrobenzoic acids

The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) 

One step process for the preparation of anticonvulsant derivatives

This invention provides a compound of Formula (I): wherein

Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4-quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula:wherein R is alkyl(C-C) prepared by reacting a substituted anthranilate with N,N-dimethylformamide dimethyacetal to obtain a N,N-dimethylamidine which is condensed with t-butylcyanoacetate to obtain a N-(2-cyano-2-t-butoxycarbonylvinyl)anthranilate, which is hydrolyzed to yield a N-(2-cyano-2-carboxyvinyl)anthranilate followed by decarboxylating to obtain a N-(2-cyano-2-carboxyvinyl)anthranilate followed by cyclizing to obtain a 3-cyano-6-alkoxy-7-nitro-4-quinolone.

Process for the synthesis of 3-cyano-6-alkoxy-7-nitro-4-quinolones

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Madison, WI, United States of America

Scott Mason Duncan