Ppd Biomarker Discovery Sciences, LLC

Surromed, Inc.

Becton Dickinson and Company Limited

Scott M Norton

Ian Walton

Louis John Dietz

James L Winkler

Christopher Hank Becker

Curtis A Hastings

Aaron B Kantor

Thomas Andrew Shaler

Remy Cromer

Byron Stephen Lee

Chih-Hua Chung

Shalom Tsur

Hua Lin

Edward Robert Holland

Sushmita Mimi Roy

Markus Anderle

Praveen Kumar

Haihong Zhou

Weixun Wang

Rebecca Louise Stoermer

Nonlinear retention time variations in chromatography-mass spectrometry data sets are adjusted by time-alignment methods, enabling automated comparison of spectra for differential phenotyping and other applications.

Methods for time-alignment of liquid chromatography-mass spectrometry data

The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

System for microvolume laser scanning cytometry

Relative quantitative information about components of chemical or biological samples can be obtained from mass spectra by normalizing the spectra to yield peak intensity values that accurately reflect concentrations of the responsible species. A normalization factor is computed from peak intensities of those inherent components whose concentration remains constant across a series of samples. Relative concentrations of a component occurring in different samples can be estimated from the normalized peak intensities. Unlike conventional methods, internal standards or additional reagents are not required. The methods are particularly useful for differential phenotyping in proteomics and metabolomics research, in which molecules varying in concentration across samples are identified. These identified species may serve as biological markers for disease or response to therapy.

Mass spectrometric quantification of chemical mixture components

Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).

Optical architectures for microvolume laser-scanning cytometers

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Durham, NC, United States of America

Scott M Norton