Johns Hopkins University

Scott M Hendrickson

David W Blodgett

Jeremiah J Wathen

Michael P McLoughlin

Mark A Chevillet

Michael J Fitch

Tomasz M Kott

Vincent R Pagan

Clare W Lau

A system includes first and second radiation sources, first and second detectors, a signal digitizer, a controller, and an analyzer. The first and second radiation sources generate respective first and second beams of radiation to irradiate a target. The first beam and second beams each include a first wavelength operated at a first modulation frequency and a second wavelength operated at a second modulation frequency. The first and second detectors each include a photo-sensitive element that generate first or second detection signals, a Faraday shielding enclosure, a signal amplifier, and a frequency mixer to frequency-adjust the first or second detection signals. The controller provides timing information to inform an activation scheme of the first and second radiation sources and corresponding radiation detection events at the first and second detectors. The analyzer analyzes the first and second detection signals and determines at least amplitude and phase information of the scattered radiation.

High sensitivity frequency-domain spectroscopy system

An optical receiver is provided that includes an array of photoreceivers. Each photoreceiver may be configured to receive a respective portion of a speckle pattern generated by interaction between an object beam and a scattering medium and each photoreceiver may be configured to generate respective electrical detection signals for provision to processing circuitry for summing of the electrical detection signals. A photoreceiver may include a collector, first detector and second detectors, and first and second optical splitters. The photoreceiver may be configured to generate a first electrical detection signal and a second electrical detection signal based on a received portion of the speckle pattern.

Multi-channel coherent detection

Example apparatuses and methods relating to imaging systems are provided. An example imaging system may include an optical source configured to generate an optical beam, a beam splitter configured to split the optical beam into a reference beam and an object beam, and a beam combiner configured to route a combined beam with reference beam and object beam components along a common path into a target medium. In this regard, the target medium may act upon the combined beam to form a common path interference beam. The example imaging system may further include an imaging sensor configured to receive the common path interference beam and generate common path interference beam data associated with the common path interference beam, and an image data processor configured to analyze the common path interference beam data to generate image data describing the target medium.

Coherent optical imaging for detecting neural signatures and medical imaging applications using common-path coherent optical techniques

An example imaging system may include a spatial light modulator and a coherent optical receiver. The spatial light modulator may be configured to receive an optical input wave and perform wavefront shaping on the optical input wave to output a shaped wave. The coherent optical receiver may include an optical local oscillator, an optical beam splitter, an optical detector, and processing circuitry. The optical detector may be configured to receive a mixed wave from the optical beam splitter that is based on the mixing of a local oscillator wave with a scattering medium output wave that at least initially comprises a speckle pattern formed by the shaped wave interacting with a scattering medium. The processing circuitry may be configured to perform coherent detection on the mixed wave to extract optical amplitude and phase information, and provide an error signal as feedback to the spatial light modulator for performing iterative wavefront shaping.

Growing community of inventors

Baltimore, MD, United States of America

Scott M Hendrickson