Johnson and Johnson Vision Care, Inc.

Johnson & Johnson Surgical Vision, Inc.

Scott L Joslin

Azaam Alli

James D Ford

Douglas G Vanderlaan

Shivkumar Mahadevan

Charles W Scales

Thomas Maggio

Yong Zhang

Bart A Johnson

Stephen C Arnold

Donnie Jerome Duis

Dola Sinha

Patricia Martin

Zohra Fadli

Eric R George

Fang Lu

Carrie L Davis

Brian Aitken

Kunisi Venkatasubban

Leah Hansen

Ghulam Maharvi

Ranganath Ramakrishnan Raja

Sharmila Muthukrishnan

C Surendran

R Sridharan

Stephen Arnold

Eric George

Disclosed are co-polymers which are produced from reactive monomer mixtures and which have both high refractive index and a high Abbe number. These materials are well suited for use as implantable ophthalmic devices and have a refractive index which may be edited through application of energy. When used for an intraocular lens, the high refractive index allows for a thin lens which compresses to allow a small incision size.

Compositions with high refractive index and Abbe number

Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.

Polymer compositions containing grafted polymeric networks and processes for their preparation and use

Disclosed are hydrophobic, acrylic materials having both high refractive index and a high Abbe number. The materials may have an internal wetting agent, are well suited for use as implantable ophthalmic devices, and have a refractive index which may be edited through application of energy. When used for an intraocular lens, the high refractive index allows for a thin lens which compresses to allow a small incision size.

High refractive index, high Abbe compositions

Compositions with high refractive index and abbe number

Provided are ophthalmic devices comprised of a reaction product of a composition comprising: (i) a crosslinked substrate network containing covalently bound activatable free radical initiators; and (ii) a grafting composition containing one or more ethylenically unsaturated compounds. Also provided are processes for making ophthalmic devices.

Ophthalmic devices derived from grafted polymeric networks and processes for their preparation and use

The present invention relates to ionic silicone hydrogel polymers displaying improved lysozyme uptake, low contact angle and reduced water soluble polymeric ammonium salt uptake.

Medical devices having homogeneous charge density and methods for making same

Described is a tri-block prepolymer having a chemical structure of [A]-[B]-[C], comprising at least one monovalent reactive group, wherein segment [A] and [C] independently comprise polymeric segments based on a first hydrophilic monomer comprising functionality selected from the group consisting of hydroxyalkyl, alkylamine, and mixtures thereof and optionally a second hydrophilic monomer, and [B] comprises a polymeric segment of at least one silicone-containing macromer and optionally a third hydrophilic monomer comprising functionality selected from the group consisting of hydroxyalkyl, alkylamine, and mixtures thereof and optionally a silicone-containing monomer. These prepolymers may be used alone or in combination with other components in reactive monomer mixtures for making silicone hydrogels and ophthalmic devices made therefrom, including contact lenses.

Tri-block prepolymers and their use in silicone hydrogels

The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80&#xb0;; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10&#xb0; higher than said extraction temperature.

Silicone hydrogels comprising N-vinyl amides and hydroxyalkyl (meth)acrylates or (meth)acrylamides

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Ponte Vedra Beach, FL, United States of America

Scott L Joslin