University of Arkansas

Scott L Ferguson

Milton Waner

Gal Shafirstein

Stephen Thomas Flock

John L Dornhoffer

Emmanuel B De Haller

An apparatus and method for thermally destroying tumors in which heat is generated by electrical resistance heating conducted to the target tissue. Computerized scanning is used to optimize the geometry of a thermal probe. The probe has a metal tip heated by a remote laser. The metal tip is mounted on the end of a wave guide fiber for transmitting the laser radiation to the metal tip. The tip is coated with a thin layer of biocompatible ceramic to avoid coagulated tissue sticking to the tip. The tip has one or more thin, thermally-conductive elements which deploy in stages to coagulate the tumor. The conductive elements may be thin wires or blades. On one embodiment, the conductive elements are composed of a shape memory material that is folded against the tip at lower temperatures and deploys at selected higher temperatures. In another embodiment, the conductive elements are blades that are deployed mechanically. The tip may be provided with a miniature thermocouple to provide temperature feedback information.

Conductive interstitial thermal therapy device

A device to guide the placement of the catheter needle more accurately by placing the needle with a mechanical firing mechanism. The device is an integrated handheld unit comprising an ultrasonic probe with a miniature display and a mechanical firing mechanism that holds the catheter needle and deploys it into the target. The device is connected to an external ultrasound machine which provides the imaging for the device. The display provides a graphical user interface to assist in alignment with the target. The depth of placement of the catheter is set by moving a horizontal indicator over the target display using thumb switches on the handle of the device. The thumb switches are connected to a servo motor or the like that adjusts the angle at which the catheter is deployed. The servo motor simultaneously adjusts the distance of the catheter from the skin of the patient to compensate for the change in the length of the path to the target caused by the change in deployment angle. The catheter needle is deployed by a stored energy mechanism. The device may also include sensors to verify accurate placement of the catheter.

Ultrasonic guided catheter deployment system

An apparatus and method for thermally destroying tumors in which heat is generated by electrical resistance heating conducted to the target tissue. Computerized scanning is used to optimize the geometry of a thermal probe. The probe has a themally conductive tip containing an electrical resistance heating element. The thermally conductive tip is mounted on the end of a fiber that contains the electrical power leads and other electrical leads connecting to monitoring devices associated with the tip. The tip is coated with a thin layer of biocompatible ceramic to avoid coagulated tissue sticking to the tip. The tip has one or more thin, thermally-conductive elements which deploy in stages to coagulate the tumor. The conductive elements may be thin wires or blades. On one embodiment, the conductive elements are composed of a shape memory material that is folded against the tip at lower temperatures and deploys at selected higher temperatures. In another embodiment, the conductive elements are blades that are deployed mechanically. The tip may be provided with a miniature thermocouple to provide temperature feedback information. The resistance heating element may be pyrolytic graphite.

A device to measure the relative location in three dimensional space of anatomical structures by injecting a beam of light into an optical imaging device and projecting the beams of light onto the object being imaged. By virtue of the change in the image of the light beam, as a function of changes in the position and/or direction of the injected beam, and knowing the optical transfer function of the imaging device, the position of the anatomical structure can easily be calculated.

Optical device for measuring small dimensions in vivo

A vibrometer which detects the variation of the speckle interference pattern of reflected waves as a means of determining the amplitude and frequency of vibrations of structures, including small anatomical structures. A wave source such as a laser delivers wave radiation to the object whose vibration is to be measured. The diffuse reflectance from the textural surface of the object reflects the incident wave radiation as a speckle interference pattern which is detected by a detector, such as a photodetector. The wave radiation source may be a continuous-wave laser, and the photodetector detector may be a phototransistor connected to a wide-bandwidth amplifier. As the object vibrates, the speckle interference pattern moves. The variation in the speckle interference pattern across the detector carries amplitude and frequency information regarding the vibrating object.

Growing community of inventors

Vilonia, AR, United States of America

Scott L Ferguson