Intelect Medical, Inc.

Boston Scientific Neuromodulation Corporation

Cornell Research Foundation Inc.

The Cleveland Clinic Foundation

The Rockefeller University

Greatbatch Ltd.

The Medical College of Wisconsin, Inc.

Scott Kokones

Keith R Carlton

David Blum

Troy Sparks

Alan Greszler

Jordan Barnhorst

John Matthew Swoyer

Michael A Moffitt

Jesse D Geroy

Gregory T Schulte

Arna Diana Ionescu

David Lubensky

Brian Hoffer

Engin Erdogan

Randall York

Ali R Rezai

G Karl Steinke

Hemant Bokil

Christopher R Butson

Andre G Machado

Nicholas D Schiff

Zhen Zeng

Bradford Curtis Fowler

Donald Pfaff

Amy Wells Quinkert

Aaron Omar Shinn

Sierra Farris

David Arthur Blum

Ketih Carlton

Electrode devices having directional electrodes for use in deep brain stimulation or other uses. In one aspect, an electrode assembly comprises an elongate lead and a lead guide that are engageable with each other in a coaxial relationship. When the elongate lead and the lead guide are engaged with each other, the two components are rotationally fixed in relation to each other. In another aspect, an elongate lead comprises a radiologically-visible feature for indicating the orientation of the elongate lead. In yet another aspect, an electrode system is capable of determining the position and/or orientation of an electrode positioned within a body. In other aspects, methods for electrically stimulating a target site in the body are disclosed.

Directional electrode devices with locating features

A system and method may include determining a target stimulation volume based on modifying a patient population image for which an efficacious volume had been determined. A system and method for suggesting stimulation devices may include determining which stimulation device is capable of producing an output volume of activation that most closely matches the target volume. A system and method for facilitating selection of stimulation parameters may include graphically identifying a maximum volume in which tissue is stimulatable by an implanted stimulation device. A system and method may pre-compute volumes of activation that result from a predetermined modification of programming settings. A system and method may transmit stimulation programming settings from a stimulation programming module to a stimulation generating device.

System and method for determining target stimulation volumes

A tool for assisting in the planning or performing of electrical neuromodulation of a patient's spinal cord. The tool may have various functions and capabilities, including calculating a volume of activation, registering an electrode(s) shown in a radiologic image, constructing functional images of the patient's spinal anatomy, targeting of neuromodulation, finding a functional midline between multiple electrodes, determining the three-dimensional position of multiple electrodes, and/or accommodating for electrode migration. In certain embodiments, the tool can be embodied as computer software or a computer system.

Programming interface for spinal cord neuromodulation

Leads having directional electrodes thereon. Also provided are leads having directional electrodes as well as anchoring prongs to secure the electrodes to the leads. Also provided are leads with directional electrodes where all the electrodes have the same surface area. Methods of treating conditions and selectively stimulating regions of the brain such as the thalamus and cerebellum are also provided.

Directional lead assembly with electrode anchoring prongs

A system for treating medical conditions by neuromodulation of one or more target sites in the nervous system. In certain embodiments, at least one of the target sites is the medial thalamic region, including the intralaminar nucleus and the adjacent white and grey matter. In certain embodiments, where there is more than one target site, the other target sites is elsewhere in the nervous system, including the globus pallidus interna, subthalamic nucleus, corpus callosum, cerebellum, cerebral cortex (including the premotor cortex, motor cortex, and sensory cortex), ventral striatum, lateral thalamus, substantia nigra, and pedunculopontine nuclei. The medical conditions include movement disorders or improvement of movement function, stroke, neuropsychiatric or neuropsychologic disorders, neurodevelopmental disorders, and pain. Methods for treating medical conditions by neuromodulation of the intralaminar nuclei either alone or in combination with another target site(s) is also provided.

Systems and methods for treating medical conditions by stimulation of medial thalamic region

A system and method for generating an estimated volume of activation (VOA) corresponding to settings applied to a stimulation leadwire includes a processor performing the following: determining, for each of a plurality of neural elements, one or more respective parameters characterizing an electrical distribution along the neural element, looking up the one or more parameters for each of the neural elements in a look-up table (LUT), obtaining threshold values for each of the neural elements recorded in the LUT in association with the looked-up parameters, comparing, for each of the neural elements, a value of the leadwire settings to each of the respective threshold value, estimating based on the comparisons which of the neural elements would be activated by the settings, and generating a structure corresponding to a region including the neural elements estimated to be activated.

VOA generation system and method using a fiber specific analysis

A system and method for associating anatomically significant regions with regions of one or more images may include automatically modifying images of different modalities according to different correction algorithms, providing a user interface for identifying a plane within three-dimensional data, scaling atlas structures to fit an anatomical image according to identified landmarks, registering an atlas to such an image via a combination of registration algorithms, and/or registering an atlas to such an image using a feature extraction algorithm.

System and method for atlas registration

A system and method for displaying a volume of activation (VOA) may include a processor that displays via a display device a model of a portion of a patient anatomy that includes anatomical structures, displays via the display device and overlying the display of the model a VOA associated by the processor with a set of anatomical stimulation parameter settings, the display of the VOA, and graphically identifies interactions between the displayed VOA and a first subset of the anatomical structures associated with one or more stimulation benefits and a second subset of the anatomical structures associated with one or more stimulation side effects, where the graphical identifications differ depending on whether the interaction is with the first subset or the second subset.

Clinician programmer system and method for generating interface models and displays of volumes of activation

A system and method for selection of stimulation parameters for Deep Brain Stimulation (DBS) may include a processor that displays in a display device and in relation to a displayed model of a leadwire including model electrodes, a current field corresponding to a first stimulation parameter set, provides a user interface for receipt of user input representing a shift of the current field, in response to the user input, moves, in the display device, the current field with respect to the displayed model, determines a second stimulation parameter set that results in the moved current field, and outputs the second stimulation parameter set and/or sets a stimulation device with the second stimulation parameter set, where the stimulation device is configured for performing a stimulation using the leadwire in accordance with the second stimulation parameter set.

Clinician programmer system and method for steering volumes of activation

Leads having directional electrodes thereon. Also provided are leads having directional electrodes as well as retention ledges to secure the electrodes to the leads. Also provided are leads with directional electrodes where all the electrodes have the same surface area. Methods of manufacturing leads and methods of treating conditions and selectively stimulating regions of the nervous system are also provided.

Directional lead assembly

Growing community of inventors

Boston, MA, United States of America

Scott Kokones