Rutgers, The State University of New Jersey

Actinobac Biomed, Inc.

Gardinnovations

University of Medicine and Dentistry of New Jersey

Scott Kachlany

Benjamin Belinka

Benjamin A Belinka, Jr

Teri Chu

Jeffrey B Kaplan

Evguenii Vinogradov

Nataliya V Balashova

Cutting board

This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.

Method of treating autoimmune inflammatory crohn's disease

An apparatus for applying a liquid to a plant growing in soil includes a handheld assembly having a spray configuration for applying a liquid to a plant as a spray at a location above the surface of the soil in which the plant is growing, and a probe configuration for applying a liquid below the surface of the soil proximate to the roots of the plant. The assembly is selectively reconfigurable by a user between the first spray configuration and the second probe configuration.

Apparatus for applying a liquid and method of use

Treatment and diagnosis of inflammatory disorders and HIV

The invention relates to pharmaceutical compositions comprising leukotoxin, including methods to treat lymphoma, and methods to diagnose lymphoma. The lymphoma includes lymphoma cells expressing activated LFA-1, and the leukotoxin binds to the activated LFA-1 on the lymphoma cells and destroys the lymphoma cells by apoptosis or necrosis, thereby treating said lymphoma.

Compositions for the treatment of cancer, and methods for testing and using the same

This invention concerns compositions and methods of treating or diagnosing ocular disease.

Treatment and diagnosis of ocular disease

The present invention provides pharmaceutical compositions comprising leukotoxin for the treatment of lung inflammation.

Methods to treat inflammation of the lung

The invention relates to pharmaceutical compositions comprising leukotoxin, a chemotherapeutic agent and a pharmaceutically acceptable carrier, including methods to treat cancer, and methods to induce apoptosis.

Combination therapy with leukotoxin

Polysaccharide-containing extracts isolated from a host cell containing nucleotide sequences encoding genes pamA, pamB and pamC, wherein the extract is capable of inhibiting biofilm formation produced by gram-negative bacteria, gram-positive bacteria and fungi, and methods to inhibit biofilm formation or remove biofilms that have already formed.

Biofilm inhibiting composition

A composition comprising leukotoxin proteins isolated from a bacterium is provided. In this composition, greater than 85% of the leukotoxin proteins are chemically modified at a basic amino acid residue, and the proteins induce cell death in myeloid leukocytes, while remaining substantially non-toxic to lymphoid leukocytes, lymphocytes, and red blood cells. Also provided is a method of selectively inducing cell death in myeloid leukocytes. The method comprises contacting the myeloid leukocytes with a composition comprising leukotoxin proteins. These leukotoxin proteins may be isolated from the NJ4500 strain of Actinobacillus actinomycetemcomitans. A method of purifying leukotoxin protein from the NJ4500 strain of Actinobacillus actinomycetemcomitans is also provided, as well as an assay that allows for the rapid determination of the activity of a given drug against leukemic cells either taken from a patient or derived from a cell line. The assay is performed in the presence of whole blood or serum.

Growing community of inventors

Bridgewater, NJ, United States of America

Scott Kachlany