University of Michigan

Depuy Synthes Products, Inc.

Wisconsin Alumni Research Foundation

Georgia Tech Research Corporation

Other

Tissue Regeneration Systems, Inc.

Scott J Hollister

William Leo Murphy

Stephen E Feinberg

James R Adox

Francesco Migneco

Leenaporn Jongpaiboonkit

Chia-Ying Lin

David A Zopf

Glenn E Green

Frank LaMarca

Paul Krebsbach

Juan M Taboas

Suman Das

Ravi K Birla

Chia Ying Lin

Tien-Min Gabriel Chu

Rachel D Maddox

Gabriel Tien-Min Chu

James K Santosa

Cheng-Yu Lin

Yen Chih Huang

Frank La Marca

Frank Lamarca

Stephn E Feinberg

A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

Scaffold for nasal tissue engineering

Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.

Modular tissue scaffolds

Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.

Ear tissue scaffold implant for auricular tissue reconstruction

Implantable splinting devices for supporting a passageway defect in a patient that is formed from one or more support structures including a polymer or a polymer and acellularized tissue matrix that define a structural component that substantially conforms to a defective passageway of the patient. The structural component also has a plurality of pores. The implantable splinting device is capable of being placed around a trachea, a bronchi, an esophagus and a blood vessel of a patient. The implantable splinting device may also be configured for placement between the trachea, and the esophagus of a patient.

Porous bidirectional bellowed tracheal reconstruction device

A biodegradable implant for use in intertransverse process spinal fusion having an absorbable matrix having a bone generating material disposed therein. A molded biodegradable case being made of bioabsorbable polymer can at least partially surround the absorbable matrix to carry a substantial portion of compression force relative to said absorbable matrix.

Biodegradable implant for intertransverse process fusion

A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and/or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls.

Degradable cage coated with mineral layers for spinal interbody fusion

Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The scaffolds are designed with a microstructure that controls elastic and permeability property distribution within the scaffold.

Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration

A biocompatible and biodegradable elastomeric polymer material, the polymer material comprising: glycerol and dodecanedioic acid, wherein the molar ratio of glycerol to dodecanedioic acid is from about 5:1 to about 1:5. Methods for using the biocompatible and biodegradable elastomeric polymer material comprises providing an PGD elastomeric polymer comprising glycerol and dodecanedioic acid, in a molar ratio of glycerol to dodecanedioic acid of about 1:1 and administering the PGD elastomeric polymer to a soft tissue defect site in needs thereof.

Polymer for tissue engineering applications and drug delivery

A method of manufacturing biodegradable/bioresorbable tissue augmentation/reconstruction devices by defining material density distributions at selected time points during a material degradation lifecycle. These different density distributions are then superposed using general linear and/or nonlinear functions that could include both time and degraded base stiffness weighting factors. The material density distribution may be created using topology optimization, image-based design or computed aided design methods to create a degradable device that retains sufficient physical properties (ie modulus, strength, electrical conductivity, thermal conductivity) through the material degradation lifecycle process. Thus, any bulk degrading material can be designed using this process for any tissue augmentation/reconstruction application.

Biodegradable/bioresorbable tissue augmentation/reconstruction device

A method of designing an interbody fusion cage is disclosed. The method uses topology optimization algorithms to define the structural layout and the inner microstructures of the cage. After the structural layout is defined, a density distribution process is performed. Based on the density distribution, the inner microstructures of the cage are defined.

Integrated global layout and local microstructure topology optimization approach for spinal cage design and fabrication

Growing community of inventors

Saline, MI, United States of America

Scott J Hollister