American Home Products Corporation

Scott J Childress

Magid A Abou-Gharbia

Guy A Schiehser

Michael W Winkley

There are disclosed compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, lower alkyl, aryl or halo, or R.sup.1 and R.sup.2 taken together represent --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --O--, --NH--, ##STR2## where the dotted lines represent optional double bonds; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each, independently, hydrogen, lower alkyl, aryl or halo;

Piperazinoisothiazolones with psychotropic activity

Disclosed herein are (lower)alkylsulfonyl derivatives of various proline amides, thiazolidine carboxylic acid amides and indoline-2-carboxylic acid amides, among others, which inhibit angiotensin converting enzyme and are antihypertensive agents.

N-(Alkylsulfonyl)-L-proline amide and N-(alkylsulfonyl)-2-carboxylic

A process for the treatment of psoriasis by systemic administration of 1-(2,6-dihalobenzylideneamino)-3-hydroxyguanidines is disclosed.

Growing community of inventors

Philadelphia, PA, United States of America

Scott J Childress