Supernus Pharmaceuticals, Inc.

Shionogi, Inc.

Scott Ibrahim

Padmanabh P Bhatt

Likan Liang

Niraj Shah

Beth A Burnside

Henry H Flanner

Donald Treacy

Marcus Schestopol

Sanna Tolle-Sander

Disclosed are pharmaceutical products for providing pulses of at least one pharmaceutically active ingredient from a patient's stomach, or from a subsequent gastrointestinal site proximal thereto, for absorption thereof at a site(s) more distal in the gastrointestinal tract than the patient's stomach, or than the subsequent gastrointestinal site proximal thereto. The product comprises first, second, and third pharmaceutical dosage forms, each of which comprises at least one pharmaceutically active agent and a pharmaceutically acceptable carrier. The product is formulated such that at least two of the first, second, and third pharmaceutical dosage forms further comprise means for providing temporary gastric-retention of the at least two of the first, second, and third pharmaceutical dosage forms within the patient's stomach, or at the subsequent gastrointestinal site proximal thereto.

Gastric release pulse system for drug delivery

The present invention is directed to oral pulse-release pharmaceutical dosage form containing an immediate release component of gamma-hydroxybutyric acid, and one or more delayed/controlled release components of gamma-hydroxybutyric acid.

Controlled release compositions of gamma-hydroxybutyrate

Growing community of inventors

Owings Mills, MD, United States of America

Scott Ibrahim