Wisys Technology Foundation, Inc.

University of Michigan

Iowa State University Research Foundation Inc

Scott Hartsel

David E Lewis

Alan A DiSpirito

Jeremy David Semrau

Sukhwan Yoon

Jeongdae Im

Sung-Woo Lee

Warren Gallagher

Marcus T McEllistrem

The present disclosures provides isolated or purified compounds, each of which bind to a metal atom. Generally, the compounds are small in size (e.g, molecular weight of less than about 1 kDa) and peptidic in nature, inasmuch as the compounds comprise amino acids. In some embodiments, the compound comprises a structure of Formula I:M-P-M-Pwherein each of Pand Pis a peptide comprising at least two amino acids, Mis a first metal binding moiety comprising a substituted imidazolone ring, Mis a second metal binding moiety comprising a substituted oxazolone ring, and wherein Mand Mbind to a single metal atom. Also provided are related complexes, conjugates, cells which synthesize the compounds of the present disclosures, substantially homogenous cultures thereof, kits and compositions, and methods of making or using the materials of the present disclosures.

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The present invention provides molecules and methods for fluorescent microscopy and visualization of biomolecules, such as cholesterol. In a preferred embodiment, the present invention provides a compound having the structure: 

Molecules and methods for fluorescence microscopy

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Eau Claire, WI, United States of America

Scott Hartsel