Cold Spring Harbor Laboratory

The University of North Carolina at Chapel Hill

The University of North Carolina

Scott Hammond

Gregory J Hannon

Emily Bernstein

Amy Caudy

Douglas S Conklin

Patrick Paddison

David H Beach

Lin He

Mohanish Deshmukh

Adam Kole

Vijay Swahari

John Michael Thomson

Summer Goodson

The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the 'target' gene).

Methods and compositions for RNA interference

The present invention relates to the regulation of apoptosis and expression of the BH3-only family of genes by miR-29. The invention further relates to the use of miR-29 to protect cells from apoptosis and to treat disorders associated with apoptosis.

Use of miR-29 for cell protection

The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the 'target' gene).

The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the mir17-92 cluster. The application further relates to screening methods to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.

Compositions and methods for cancer diagnosis and treatment

Methods and compositions for RNA interference using recombinant Dicer and Argonaut

Growing community of inventors

Pittsboro, NC, United States of America

Scott Hammond