Medivation Prostate Therapeutics, Inc.

Transition Therapeutics Ireland Limited

Elan Pharmaceuticals, Inc.

Scott Greenfield

Andrew S Thompson

Rajendra Parasmal Jain

Remy Angelaud

Carol Lamberson

Andrew Thompson

Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds

Methods of synthesis of scyllitol diborate and related compounds are provided, including methods that are performed in all-aqueous solutions. Also provided are methods in which the reaction products are recycled to increase the efficiency of the process. The methods include the steps of conversion of a solution of inositol to scyllitol, conversion of scyllitol in the solution to scyllitol diborate, and isolation of the scyllitol diborate from the solution. The scyllitol diborate is reacted to form substantially pure scyllitol diborate, and the remaining solution is efficiently recycled to scyllitol diborate, then to additional substantially pure scyllitol. This scyllitol diborate recycling step can be applied to a variety of processes to improve the yield of scyllitol. The methods are highly efficient and result in large scale reaction products of high purity.

Methods of synthesis of scyllitol and related compounds

Growing community of inventors

Delmar, NY, United States of America

Scott Greenfield