Quest Diagnostics Investments, Inc.

Quest Diagnostics Investments Incoporated

Scott Goldman

Julie A Neidich

Nigel J Clarke

Darren J Weber

Mildred M Goldman

Michael McPhaul

Thomas C Lynn

Julia Colletti

Michael P Caufield

Denise Salazar

This disclosure provides methods for quantifying individual amino acids in various bodily fluids obtained from a human patient. Also provided are reference ranges for normal amino acid levels in the various bodily fluids (e.g., blood plasma, urine, cerebrospinal fluid, and saliva) and for various age groups (e.g., neonates, infants, children, and adults).

Analysis of amino acids in body fluid by liquid chromatography—mass spectrometry

The invention relates to the detection of methylmalonic acid (MMA). In a particular aspect, the invention relates to methods for detecting derivatized methylmalonic acid (MMA) by mass spectrometry.

Mass spectrometric determination of tert-butyldimethylsilyl derivatized methylmalonic acid

The invention relates to the detection of fatty acids. In a particular aspect, the invention relates to methods for detecting very long chain fatty acids and branched chain fatty acids by mass spectrometry.

Mass spectrometric determination of fatty acids

Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.

Mass spectrometric determination of testosterone in multiplexed patient samples

Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.

Methods for detecting chromogranin a by mass spectrometry

The invention relates to the detection of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.

Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid

Analysis of amino acids in body fluid by liquid chromotography-mass spectrometry

Mass spectrometric determination of derivatized methylmalonic acid

The invention relates to the detection of DHA and EPA. In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.

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Laguna Niguel, CA, United States of America

Scott Goldman