Millennium Pharmaceuticals Limited

Scott Freeze

Koji Ono

Steven P Langston

He Xu

Hirotake Mizutani

Matthew O Duffey

Dylan Bradley England

Zhigen Hu

Charles McIntyre

Charles Mcintyre

Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof; wherein Y, R, R, R, R, X, X, X, R, Z, and Zhave the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

Heteroaryl compounds useful as inhibitors of SUMO activating enzyme

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Boston, MA, United States of America

Scott Freeze