Other

Sri International

Eisai R&d Management Co., Ltd.

Vertex Pharmaceuticals, Inc.

Novellus Systems Incorporated

Scott Fields

Lynn D Hawkins

Sally T Ishizaka

Daniel P Rossignol

Joseph Anthony Perrone

Rajeev Vaidyanathan

Stephen B Richter

Ellen Beaulieu

Shambhu Nath Roy

Philip Michael Reaper

Vincent Burkhart

John Robert Pollard

Mohammed Asmal

Thomas C Marin

Peter Littlewood

Mori Nobuyuki

Yamanishi Yoshiharu

Julian A Gray

Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein. 

Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors

Ectoparasite infestation of a substrate like bedding is detected by contacting a sample from the substrate with a polyclonal ectoparasite antibody generated from a whole ectoparasite immunogen, under conditions wherein the antibody specifically binds ectoparasite antigen in the sample.

Ectoparasite detection

A wafer support assembly including a wafer support and cooling plate with radial thermal chokes is provided. The cooling plate and wafer support may have limited contact and may not contact each other outside of certain limited thermal contact patches. The thermal contact patches may generally define one or more radial thermal choke regions. In some implementations, high- and low-temperature cooling systems may be placed at one or more locations across the cooling plate to assist in temperature management.

High temperature electrostatic chuck with radial thermal chokes

The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.

Compositions and methods for cancer immunotherapy

A method for playing a lotto type lottery game. The method comprises the following steps: selling a first plurality of lottery tickets for a lotto style lottery game in which prizes are paid out at both the jackpot and sub-jackpot levels; drawing a first winning combination; and selling a second plurality of tickets for a subsequent game such that said first plurality of lottery tickets may be reutilized for the jackpot prize level of a subsequent drawing.

Method of playing a lottery game

A device for generating winning lotto and keno combinations. The invention comprises means for inputting a number comporting to the total size of a lottery number pool; keypad means for inputting a minimum winning prize level; means in accordance with a prestored algorithm for generating a plurality of number combinations utilizing each number in said number pool, said number combinations guaranteeing a winning combination at said a minimum prize level; and means for outputting said number combinations.

Apparatus and method for generating number sets

Growing community of inventors

Towaco, NJ, United States of America

Scott Fields