Other

University of California

Novartis Ag

Scott F Geller

John G Flannery

Robert L Hunsinger, Iii

Karen I Guerin

The present disclosure provides recombinant adeno-associated virus (AAV) virions comprising: a) a variant capsid protein; and b) a heterologous nucleic acid comprising one or more nucleotide sequences encoding one or more heterologous gene products. The rAAV virions are useful for delivery of gene products to a retinal cell. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.

Adeno-associated virus virions with variant capsids and methods of use thereof

A fluid sensing device, including a housing; a fluid flow sensor at least partially contained within the housing and adapted to detect a flow of fluid through the housing; a timer operably connected to the fluid flow sensor and at least partially contained within the housing, the timer receiving a start signal from the fluid flow sensor when the fluid flow sensor detects the onset of fluid flow, the timer receiving a stop and reset signal from the fluid flow sensor when the fluid flow sensor detects the end of fluid flow; and at least one signaling device operably connected to the timer such that the signaling device is actuated when the timer indicates that a predetermined amount of time has elapsed.

Growing community of inventors

El Cerrito, CA, United States of America

Scott F Geller