Eli Lilly and Company

Scott Eugene Connor

Guoxin Zhu

Robert Jason Herr

Nathan Bryan Mantlo

The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R2 is selected from the group consisting of C-Calkyl and C-heteroalkyl; (b) X is selected from the group consisting of a single bond, O, S, S(O)and N; (c) U is an aliphatic linker wherein one carbon atom of the aliphatic linker is optionally replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with from one to four substituents each independently selected from R30; (d) Y is selected from the group consisting of C, O, S, NH and a single bond; and (e) E is C(R3)(R4)A or A.

Growing community of inventors

Indianapolis, IN, United States of America

Scott Eugene Connor