Lyell Immunopharma, Inc.

Scott Edward Boyken

Marc J Lajoie

Howell Franklin Moffett

Blythe Sather

Byoung Ryu

Spencer Park

Queenie Vong

Bijan Boldajipour

Brian Weitzner

Yun Song

Neeraj Sharma

Shobha Potluri

The present disclosure relates to polynucleotides encoding a chimeric polypeptide comprising a c-Jun polypeptide, a ROR1-binding protein, and a truncated EGF receptor. Also provided are cells (e.g., T cells) expressing CARs comprising a ROR1-binding protein and overexpressing a c-Jun polypeptide. Overexpression of c-Jun in CAR T cells confers improved properties, e.g., reducing or preventing exhaustion.

ROR1 targeting chimeric antigen receptor

The present disclosure relates to EGFR-derived polypeptides containing short juxtamembrane sequences, nucleic acids encoding them, and methods of using them to improve cell surface expression of truncated EGFR markers.

Recombinant cell surface markers

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Seattle, WA, United States of America

Scott Edward Boyken