E.i. Dupont De Nemours and Company

The Dupont Merck Pharmaceutical Company

Scott E Loveless

Neil R Ackerman

Richard R Harris

Russell H Neubauer

Bruce D Jaffee

Russel H Neubauer

4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, organ transplantation rejection, graft vs. host disease, multiple sclerosis, and chronic inflammatory diseases such as rheumatoid arthritis.

4-quinoline carboxylic acid derivatives useful as immunosuppressive

4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, organ transplantation rejection, graft vs. host disease, multiple sclerosis, and chronic inflammatory diseases such as rheumatoid arthritis.

4-Quinoline carboxylic acid derivatives useful as immunosuppressive

Phenylquinolinecarboxylic acids and derivatives thereof, such as 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, or a sodium or potassium salt thereof, are useful for the treatment of skin and muco-epithelial diseases.

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Newark, DE, United States of America

Scott E Loveless